NFL Week 12 Score Predictions: Who Wins Every Game This Weekend?

NFL Week 12 score predictions arrive at a pivotal moment in the 2025 season. The playoff race is tightening, several division battles remain unsettled, and a handful of teams enter the weekend fighting to keep their seasons alive. With 13 matchups still to be played, Week 12 sets the tone for the final month of the year.

Some teams enter the week trending upward behind efficient offenses and stable quarterback play. Others face questions around injuries, turnovers and defensive breakdowns. These predictions use team form, statistical trends and current depth-chart updates to project how all remaining Week 12 games may unfold.

Full NFL Week 12 Score Predictions

Already played: Texans 23, Bills 19 (Final).

Steelers at Bears Prediction: Bears 24, Steelers 20
Chicago has leaned on its run game and improving defense. Pittsburgh’s inconsistency on offense remains a concern, and injuries under center reduce their scoring ceiling. The Bears’ balance at home gives them a slight advantage.

Patriots at Bengals Prediction: Patriots 31, Bengals 21
New England enters as one of the hottest teams in football with a steady offense and a disciplined pass rush. Cincinnati continues to struggle defensively and remains unsettled at quarterback. The Patriots’ efficiency should carry them.

Giants at Lions Prediction: Lions 34, Giants 17
Detroit’s offense operates at a high level when controlling the line of scrimmage. New York has struggled to stop the run all season. The Lions are well positioned to rebound from last week’s loss with a strong showing.

Vikings at Packers Prediction: Packers 27, Vikings 16
Green Bay’s defense has been a steady force, especially at home. Minnesota’s passing game remains volatile with turnovers creating short fields for opponents. The matchup favors the Packers’ speed and pressure.

Seahawks at Titans Prediction: Seahawks 27, Titans 13
Seattle continues to look like a playoff-caliber team thanks to strong play up front. Tennessee, despite competing hard, struggles to finish drives and generate big plays. The Seahawks’ consistency should create separation by halftime.

Colts at Chiefs Prediction: Colts 28, Chiefs 27
This projects as one of the closest games of the week. Kansas City’s offense has been up-and-down, while Indianapolis enters with fresh legs after a bye. A powerful Colts run game could tilt a late possession.

Jets at Ravens Prediction: Ravens 26, Jets 16
Baltimore’s ability to pressure quarterbacks and force turnovers should be the difference. The Jets have lacked explosive plays and continue to struggle on the road. The Ravens’ balanced roster earns the home victory.

Browns at Raiders Prediction: Browns 20, Raiders 17
Cleveland’s defense has carried the team despite a losing record. Las Vegas battles through offensive inconsistency, especially against physical fronts. A defensive takeaway or short field may decide this one for the Browns.

Jaguars at Cardinals Prediction: Jaguars 28, Cardinals 23
Jacksonville’s offense finally showed rhythm last week. Arizona plays tough but has allowed long late-game drives several times this season. The Jaguars’ play-action attack should be just enough to escape with a win.

Eagles at Cowboys Prediction: Eagles 27, Cowboys 24
Philadelphia’s trenches continue to be the backbone of the team. Dallas has improved defensively but still struggles in key moments. Expect a competitive game that comes down to a fourth-quarter possession.

Falcons at Saints Prediction: Falcons 23, Saints 20
Atlanta leans on its stars to snap a losing streak. New Orleans has struggled to generate explosive plays and may have difficulty matching the Falcons’ offensive pace for four quarters. A late drive could swing it.

Buccaneers at Rams Prediction: Rams 30, Buccaneers 21
Los Angeles enters Week 12 with one of the league’s most complete rosters. Tampa Bay competes but often stalls in the red zone on the road. The Rams’ passing rhythm remains the x-factor.

Panthers at 49ers Prediction: 49ers 27, Panthers 20
San Francisco looks recharged with more stability on offense. Carolina plays with energy and can keep the game close early, but containing the 49ers’ front seven over four quarters is a major challenge.

How Week 12 Could Shift the Playoff Picture

Several outcomes in these NFL Week 12 score predictions carry playoff implications. A Chiefs loss would tighten the AFC West race. Wins by the Eagles and Rams would reinforce their NFC dominance. Meanwhile, the Titans, Jets, Raiders and Bengals risk falling out of postseason contention entirely with another defeat.

Week 12 offers statement opportunities for teams rising at the right time and crossroads moments for clubs trying to salvage their seasons. The final month of the year is set up by what happens today.

These NFL Week 12 score predictions reflect current form, depth, and matchup strength heading into Sunday and Monday. The results will determine which teams carry momentum into December..