NFL Week 13 Injury Report Everything We Know About Key Player Updates

The NFL Week 13 Injury Report highlights major quarterback and skill position injuries across the league as teams prepare for the December slate. Several key starters, including Baker Mayfield and Aaron Rodgers, face important health decisions ahead of kickoff. The latest reports confirm which players are out, which are returning, and which remain questionable for the weekend.

This week features wide-ranging updates that affect depth charts and game plans. Teams such as the Buccaneers, Steelers, Jaguars, and Saints face significant changes due to injuries at quarterback, running back, and wide receiver. Officials across teams and league insiders reported updated statuses throughout November 29.

Latest Week 13 Injury Updates Across All Matchups

Week 13 features one of the busiest injury slates of the season. According to updates reported by major outlets including Reuters and AP, several quarterbacks returned to full participation while others were ruled out. Baker Mayfield remains questionable with a left shoulder injury after exiting last week’s game. Tampa Bay coach Todd Bowles said the team expects him to play, but the decision will be made after warmups.

In Pittsburgh, Aaron Rodgers has been cleared to return after missing time with a left wrist fracture. He will start against Buffalo. Steelers receiver DK Metcalf is expected to play after an ankle issue limited him earlier in the week.

New Orleans will be without Alvin Kamara due to a knee injury. Chris Olave remains questionable after experiencing back tightness. Both issues significantly affect a Saints offense already adjusting to a rookie quarterback.

The Texans and Colts both confirmed their starting quarterbacks are available. C. J. Stroud will return for Houston after a three week absence caused by a concussion. Indianapolis quarterback Daniel Jones continues to play through a fibula fracture, a condition reported earlier this week.

Atlanta will again be without Drake London due to a knee injury. The Falcons are also adjusting to Kirk Cousins under center for the remainder of the season after losing Michael Penix Jr. to injury.

San Francisco and Cleveland reported no major changes. Christian McCaffrey missed practices earlier in the week for rest purposes only and is expected to play. No significant injury absences were announced for either roster.

The Panthers will be without Jaycee Horn due to a concussion. His absence affects Carolina’s secondary against a strong Rams receiving corps led by Puka Nacua and Davante Adams.

Jacksonville confirmed Brian Thomas Jr. will return after missing three games with an ankle injury. Tennessee tight end Chig Okonkwo is questionable with a foot issue, potentially increasing reps for rookie Gunnar Helm.

Arizona faces the largest cluster of injuries. Trey Benson and Emari Demercado are out. Bam Knight is questionable. Marvin Harrison Jr. could return after recovering from appendicitis. Tampa running back Bucky Irving is also questionable but trending toward playing for the first time since Week 4.

Minnesota will be without J. J. McCarthy due to a concussion. Undrafted rookie Max Brosmer will start behind an offensive line missing multiple players. Seattle enters as the healthier team.

Buffalo tight end Dalton Kincaid is questionable with a hamstring injury. Offensive tackles Dion Dawkins and Spencer Brown are out. This forces the Bills to adjust protections against a strong Pittsburgh pass rush.

Los Angeles Chargers rookie Omarion Hampton remains out with an ankle injury despite returning to practice. Kimani Vidal will handle lead back duties once again.

Washington quarterback Jayden Daniels remains out with a left elbow injury. Terry McLaurin returns from a quad injury and will start. Marcus Mariota will lead the Commanders against a Denver defense ranked third in scoring.

The Giants confirmed Jaxson Dart will return from a concussion. His start comes with New England missing left tackle Will Campbell and guard Jared Wilson. This creates protection challenges for a Patriots line already impacted by earlier injuries.

How These Week 13 Injuries Shape Team Outlooks

The NFL Week 13 Injury Report shows several playoff hopefuls navigating health complications. Teams like Tampa Bay and Pittsburgh regain key starters, strengthening competitive outlooks. Others, such as Minnesota, Arizona, and New Orleans, experience significant roster strain due to repeated injuries at skill positions.

The return of high profile players such as C. J. Stroud, Brian Thomas Jr., and DK Metcalf provides needed support for teams battling for divisional position. Conversely, the absences of Alvin Kamara, Drake London, Omarion Hampton, and Jaycee Horn signal potential challenges for continuity and execution.

Persistent injuries to offensive lines for Buffalo and New England also raise efficiency concerns. These units will rely on backups in high pressure games heading into December. The final stretch of the season will test roster depth across the league.

The NFL Week 13 Injury Report underscores shifting team dynamics as the league enters its final six weeks. Health, depth, and timely returns may determine which teams maintain momentum into the playoff race.

FYI (keeping you in the loop)-

Q1: Who are the biggest names on the NFL Week 13 Injury Report?

Major names include Baker Mayfield, Aaron Rodgers, Alvin Kamara, Drake London, J. J. McCarthy, and Marvin Harrison Jr. Several running backs across Arizona are also out.

Q2: Is Baker Mayfield expected to play in Week 13?

He is listed as questionable due to a left shoulder injury. Tampa coach Todd Bowles said the team expects he will play if he clears final checks.

Q3: Which quarterbacks are confirmed out in Week 13?

J. J. McCarthy and Jayden Daniels are out. Other quarterbacks such as Aaron Rodgers and C. J. Stroud are cleared to return.

Q4: Which teams are most affected by injuries this week?

Arizona, New Orleans, Minnesota, and Tampa Bay face the most significant lineup changes. These include absences at running back, quarterback, and cornerback.

Q5: Is Marvin Harrison Jr. playing in Week 13?

He is listed as questionable while recovering from appendicitis. Team officials are optimistic he may return.