Brock Purdy Injury Update: Will 49ers QB Play in Week 6 vs. Buccaneers?

Brock Purdy will miss the San Francisco 49ers’ Week 6 matchup against the Tampa Bay Buccaneers on Sunday, Oct. 12, 2025. The star quarterback has been ruled out due to toe and shoulder injuries, leaving the NFC West leaders without their starting signal-caller once again.

The 49ers, who enter Week 6 with a 4-1 record, have been plagued by injuries all season. Purdy first sustained the injuries in Week 1 and aggravated his toe issue upon returning in Week 4. Despite optimism earlier in the week, he did not participate in practice and was officially ruled out on Friday.

Brock Purdy Injury Update: Status Confirmed for Week 6

The 49ers announced that Brock Purdy will not suit up against the Buccaneers, marking his fourth missed game of the 2025 season. Purdy played in Week 4 against the Jacksonville Jaguars but suffered a setback, which sidelined him once again. However, the team has not placed him on injured reserve, signaling that they expect him back in the coming weeks.

San Francisco continues to face significant challenges on offense. Star receiver Brandon Aiyuk remains sidelined with a torn ACL, and All-Pro tight end George Kittle has not played since suffering a hamstring injury in Week 1. Wideout Ricky Pearsall is also out, missing his second consecutive game.

In Purdy’s absence, veteran quarterback Mac Jones is expected to make his fourth start of the season. Jones previously led the 49ers to three straight wins in Weeks 2, 3, and 5 — including a 26-21 road victory over the New Orleans Saints, a narrow 16-15 home win against the Arizona Cardinals, and a thrilling Thursday night upset over the Los Angeles Rams.

San Francisco’s quarterback depth chart remains thin. Adrian Martinez, who has been elevated from the practice squad three times this season, is the next man up. Kurtis Rourke remains on the non-football injury list. If Jones, who is listed as questionable with knee and oblique injuries, cannot play, Martinez would make his first career NFL start.

How Purdy’s Absence Impacts the 49ers’ Season

Purdy’s absence comes at a crucial point in the 49ers’ campaign. San Francisco is battling to stay atop the NFC West, and continuity at quarterback will be key as the season progresses. Despite multiple injuries to offensive stars, the team has shown resilience, winning all three games started by Jones so far.

The Buccaneers (4-1) enter Week 6 as one of the NFC’s top teams, adding extra pressure on San Francisco’s offense to perform without its starting quarterback. If Jones is cleared to play, the 49ers will rely on a balanced attack and strong defense to secure another win. If Martinez starts, the team will need to simplify the game plan and lean heavily on the run game and defense.

Brock Purdy’s recovery will be closely monitored in the coming weeks. The 49ers remain hopeful he can return soon as they continue their push for a deep playoff run.

FYI (keeping you in the loop)-

Q1: Will Brock Purdy play in Week 6 vs. Buccaneers?

No, Purdy has been ruled out for Week 6 due to toe and shoulder injuries. He did not participate in practice and remains sidelined.

Q2: When could Brock Purdy return?

The 49ers did not place Purdy on injured reserve, indicating they expect him back within the next few weeks.

Q3: Who will start for the 49ers in Purdy’s absence?

Mac Jones is expected to start if healthy. If he is unavailable, Adrian Martinez would make his first NFL start.

Q4: How have the 49ers performed without Purdy?

San Francisco is 3-0 in games started by Mac Jones this season, showcasing strong depth and resilience despite key injuries.

Q5: What other injuries are affecting the 49ers?

Brandon Aiyuk, George Kittle, Ricky Pearsall, and Jauan Jennings have all missed time, significantly impacting the offense.