Advertisement Brock Purdy will miss the San Francisco 49ers’ Week 6 matchup against the Tampa Bay Buccaneers on Sunday, Oct. 12, 2025. The star quarterback has been ruled out due to toe and shoulder injuries, leaving the NFC West leaders without their starting signal-caller once again. The 49ers, who enter Week 6 with a 4-1 … Continue reading Brock Purdy Injury Update: Will 49ers QB Play in Week 6 vs. Buccaneers?