Brock Purdy Latest Injury Update: Will 49ers QB Play Week 6 Game vs. Buccaneers?

San Francisco 49ers quarterback Brock Purdy’s status for Week 6 remains uncertain as the team prepares to face the Tampa Bay Buccaneers on Sunday. The starter missed Wednesday’s practice due to lingering toe and shoulder injuries, raising doubts about his availability. With the NFC West leaders holding a 4-1 record, fans are anxious to know if Purdy will return under center or if backup Mac Jones will get another start.

Purdy’s injury stems from a Week 1 win over the Seattle Seahawks. He missed the following two games, during which Jones stepped in and led the 49ers to victories over the Saints and Cardinals. Although Purdy returned in Week 4, he did not appear fully healthy. Jones reclaimed the starting role in Week 5 and secured an overtime win against the Los Angeles Rams, keeping San Francisco atop the division.

Latest on Brock Purdy’s Practice Status and Week 6 Outlook

Brock Purdy did not participate in practice on Thursday, according to multiple reports. He was among three key starters sidelined, including wide receivers Jauan Jennings and Ricky Pearsall. Meanwhile, Mac Jones was listed as a limited participant as he recovers from knee and oblique issues.

The fact that Purdy hasn’t practiced yet this week is concerning, but it doesn’t rule him out entirely. The 49ers will hold additional sessions on Friday, and Purdy’s participation—or lack thereof—will be a critical indicator of his Week 6 status. Importantly, the team has not placed him on Injured Reserve, which would require him to miss at least four games. This suggests they believe his return is possible within the next one or two weeks.

San Francisco’s quarterback depth chart currently includes Purdy (injured), Jones (expected starter), and Adrian Martinez, who was elevated from the practice squad in Week 5 as an emergency option. If Purdy is unable to play Sunday, Martinez will likely dress again as the backup behind Jones.

With back-to-back NFC South matchups coming up—against the Buccaneers in Week 6 and the Falcons in Week 7 on “Sunday Night Football”—the 49ers are expected to prioritize long-term health over rushing Purdy back too soon. Head coach Kyle Shanahan has emphasized that player recovery remains the top priority, even with playoff positioning on the line.

What Purdy’s Absence Could Mean for the 49ers

If Purdy is sidelined again, the 49ers will rely on Jones, who has shown poise and command of the offense in his appearances. However, Jones is also managing minor injuries, and any setback could thrust Martinez into action—an untested scenario for a team with Super Bowl aspirations.

Purdy’s absence could also impact San Francisco’s offensive rhythm. The team has leaned heavily on its run game and short passing attack to accommodate its quarterback situation, but facing a 4-1 Buccaneers defense that ranks among the NFL’s top five in points allowed will test that approach.

For now, all signs point to Purdy being a game-time decision. His status in Friday’s practice will likely determine whether he suits up on Sunday or gives Jones another chance to lead the 49ers’ offense.

FYI (keeping you in the loop)-

Q1: Did Brock Purdy practice this week?

No, Purdy missed Wednesday and Thursday practices as he recovers from toe and shoulder injuries. His Friday participation will be key to his Week 6 status.

Q2: Who will start for the 49ers if Purdy can’t play?

Mac Jones is expected to start if Purdy is unavailable. Adrian Martinez will serve as the backup if needed.

Q3: Has Purdy been placed on injured reserve?

No, the 49ers have not placed Purdy on IR, suggesting they expect him back sooner rather than later.

Q4: What is the 49ers’ current record?

San Francisco leads the NFC West with a 4-1 record and a perfect 3-0 mark in divisional games.

Q5: When do the 49ers face the Falcons?

They will host the Atlanta Falcons in Week 7 on “Sunday Night Football.”