Hidden Cancer Risk Genes Found in 17 Million Americans, Study Reveals

A new study reveals millions of Americans carry genetic mutations that raise their cancer risk. The research was published this week in the Journal of the American Medical Association. It suggests these mutations are far more common than previously believed.

The findings challenge current medical guidelines for genetic testing. They indicate that family history alone may not be a reliable indicator of risk. This could have major implications for cancer screening protocols nationwide.

Widespread Genetic Risk Uncovered

As many as 5% of the U.S. population carries these variants. This translates to roughly 17 million people. The study analyzed over 70 common cancer-related genes.

Researchers identified more than 3,400 unique mutations. These mutations are linked to a higher chance of developing cancer. The presence of these genes is not dependent on lifestyle or family history.

Senior researcher Dr. Joshua Arbesman from the Cleveland Clinic commented on the results. He stated that genetic testing has traditionally been for high-risk individuals. The new data shows many with pathogenic variants fall outside these criteria.

Implications for Cancer Screening and Prevention

The study suggests a need for broader access to genetic testing. Routine screenings like mammograms could become more widely recommended. Early detection remains a critical defense against cancer.

Researchers hope this leads to more proactive healthcare. The goal is to identify at-risk individuals earlier. This could significantly improve cancer outcomes through preventative measures.

According to Reuters coverage, this research builds on prior work by the same team. Earlier findings showed genetic predisposition to melanoma was vastly underestimated. The current study confirms a broader pattern across multiple cancer types.

The discovery of widespread hidden cancer risk genes underscores a pressing need to reevaluate preventative healthcare strategies for the entire population, not just those with a known family history.

Thought you’d like to know-

What percentage of people have these cancer risk genes?

Approximately 5% of the U.S. population carries them. This equals about 17 million Americans. The number was uncovered through a large-scale genetic study.

Should I get genetic testing if I have no family history?

The study suggests family history is not a perfect indicator. Many with the mutations had no known family risk. Discussing options with a healthcare provider is a prudent step.

Which cancers are linked to these genetic mutations?

The research analyzed over 70 cancer-related genes. These are associated with a range of cancers. The study aims to build a comprehensive list for future screening guidance.

How will this study change cancer screening recommendations?

It may lead to broader access to genetic testing. It also supports routine screenings for more people. The focus is on early detection and prevention for the general population.

Who conducted this research?

The study was led by researchers from the Cleveland Clinic. It was published in the Journal of the American Medical Association. The team included experts in genetics and oncology.