Celtics vs 76ers Prediction: Can Boston End Philadelphia’s Perfect Start in NBA Cup Clash?

The Philadelphia 76ers and Boston Celtics face off tonight in a high-stakes 2025 NBA Cup showdown at Xfinity Mobile Arena in Philadelphia. The 76ers (4-0) remain unbeaten this season, while the Celtics (2-3) aim to build on their recent two-game winning streak. According to SportsLine’s consensus, Boston enters as a narrow 1-point favorite, with the total set at 233.5 points.

Tipoff is scheduled for 7 p.m. ET, with both teams eager to make an early statement in the NBA’s new in-season competition. Philadelphia will be without Paul George (knee) and Jared McCain (thumb), while Boston continues to navigate Jayson Tatum’s Achilles injury.

Key Betting Insights and Statistical Breakdown

SportsLine’s computer model simulated the Celtics vs 76ers matchup 10,000 times, projecting a tight battle between the Atlantic Division rivals. The model has been on a strong run, posting a 161-120 record on top-rated NBA picks and delivering nearly $4,000 in returns to bettors following its advice. Historically, it has been accurate in identifying over/under trends, leaning toward an “Under” with 231 total projected points for this contest.

Boston remains slightly favored (-115 on the moneyline) despite losing the season opener to Philadelphia earlier this month. In that matchup, Sixers rookie VJ Edgecombe stole the spotlight with 34 points, seven rebounds, and three assists, helping Philadelphia secure a narrow 117-116 win at TD Garden. The Celtics’ focus now shifts to containing Tyrese Maxey, who’s averaging 37.5 points, 8.3 assists, and 3.8 rebounds over his first four games.

Meanwhile, Jaylen Brown continues to anchor Boston’s offense in Tatum’s absence. The veteran guard is averaging 26.8 points, 5.6 rebounds, and 3.8 assists, including a 30-point performance in the win over Cleveland. Derrick White has also contributed consistently, averaging 17 points with strong defensive numbers.

Players to Watch and Game Analysis

For the 76ers, Maxey’s explosive scoring and Edgecombe’s confidence have made up for the temporary absence of Paul George. Their offensive tempo has kept defenses scrambling, especially in late-game situations. Philadelphia’s home-court advantage (2-0 this season) could also be a crucial factor in maintaining momentum.

Boston’s success hinges on defensive efficiency and outside shooting. If Brown and White can combine for over 45 points, and the Celtics’ bench delivers consistent support, they have a chance to hand the Sixers their first loss. Expect Al Horford and Kristaps Porziņģis to play key roles in limiting second-chance opportunities and protecting the rim against Philadelphia’s aggressive guards.

Prediction: While the 76ers have been the hotter team, Boston’s improved defensive structure and veteran leadership could tilt the balance. Expect a close finish, but the Celtics may edge out a 116–113 win to level their record at 3-3.

FYI (keeping you in the loop)-

Q1: Who is favored in the Celtics vs 76ers game?

Boston is a 1-point favorite, according to the latest consensus odds from SportsLine.

Q2: What time does the Celtics vs 76ers game start?

Tipoff is scheduled for 7 p.m. ET from Xfinity Mobile Arena in Philadelphia.

Q3: What is the over/under for Celtics vs 76ers?

The total points line is set at 233.5, with the SportsLine model projecting slightly under at 231 combined points.

Q4: Which players are injured for both teams?

Jayson Tatum remains out for the Celtics with an Achilles injury, while Paul George (knee) and Jared McCain (thumb) are sidelined for the 76ers.

Q5: Where can fans stream the Celtics vs 76ers game?

The game will be available for streaming on Amazon Prime.