Christian McCaffrey Injury Update: Will 49ers RB Play vs Cardinals in Week 11?

Christian McCaffrey appears on the Week 11 injury report, but the star running back is expected to play when the San Francisco 49ers meet the Arizona Cardinals on November 16. The main keyword, Christian McCaffrey injury update, remains the focus as the team enters a critical NFC West matchup.

San Francisco listed McCaffrey as a non-participant earlier in the week, though it was designated as a rest-related absence. He carries no official game status heading into Sunday. That signals confidence from the team that their top offensive weapon will be available.

Latest Status in the Christian McCaffrey Injury Update

McCaffrey’s week began with a “did not participate” label, but it was classified under rest, not injury. That has been a familiar pattern for the 49ers, especially when managing his workload during the long season. The team did not assign a questionable, doubtful, or out designation on the final report, indicating that he is on track to play against the Cardinals.

McCaffrey continues to lead the 49ers in both rushing and receiving production. He has 626 rushing yards on 180 carries and four rushing touchdowns in 2025. He also leads the team in receiving yards with 692 yards and four receiving touchdowns. His dual-threat production remains central to San Francisco’s offense, which ranks among the most balanced in the NFL.

In his most recent performance in Week 10, he logged 12 carries for 30 yards and added 8 receptions for 66 yards. While not his most explosive day, it reinforced how involved he remains as both a runner and pass-catcher. As reported by AP and other outlets, the 49ers’ staff has emphasized strategic rest to preserve McCaffrey for the second half of the season.

The 49ers face Arizona at 4:05 p.m. ET on FOX, a matchup they won earlier this season. In that Week 3 meeting, McCaffrey posted 52 rushing yards and 88 receiving yards. His involvement in both phases will again be critical as the team pushes toward the postseason.

McCaffrey’s Role in a Must-Win Stretch for San Francisco

The 49ers continue to rely heavily on McCaffrey’s versatility. His production keeps defenses off balance and opens opportunities for their play-action attack. With the NFC playoff picture tightening, his presence becomes even more important.

Fans have reacted positively to the latest Christian McCaffrey injury update, noting that the rest designation should allow him to stay fresh. Analysts also highlight that keeping him healthy down the stretch is a priority, especially with several high-stakes games ahead.

McCaffrey’s status for Week 11 appears solid. The Christian McCaffrey injury update points to him playing as normal in a key divisional matchup. Barring setbacks, he should remain the centerpiece of the 49ers’ offensive plan against Arizona.

FYI (keeping you in the loop)-

Q1: Is Christian McCaffrey playing in Week 11?

Yes. The latest information shows he has no game status designation and is expected to play vs. the Cardinals.

Q2: Why was Christian McCaffrey listed as DNP?

He received a rest day, which the 49ers commonly give veteran players. It was not injury related.

Q3: How has Christian McCaffrey performed in 2025?

He leads the team in both rushing and receiving, totaling 626 rushing yards and 692 receiving yards.

Q4: Did McCaffrey play earlier this season vs. Arizona?

Yes. He produced 140 combined yards in their first meeting in Week 3.

Q5: Who backs up Christian McCaffrey?

The 49ers have no other running back on this week’s injury report, signaling full availability behind him.