The Indianapolis Colts face a must-win game against the San Francisco 49ers this Monday. The Week 16 matchup kicks off at Lucas Oil Stadium. Key injuries threaten to derail the Colts’ fading playoff hopes.

According to the team’s final injury report, several starters are questionable or out. This comes after a crushing last-second loss to the Seattle Seahawks.
Star Defender Buckner Questionable, Key Starters Ruled Out
The Colts’ defense took significant hits. Star defensive tackle DeForest Buckner is listed as questionable. He missed practice with a neck issue and for rest.
Cornerback Sauce Gardner will not play due to a calf injury. His absence is a major blow to the secondary. Wide receiver Anthony Gould is also out with a foot problem.
A positive note is quarterback Anthony Richardson Sr. returning to practice. He remains on Injured Reserve recovering from an eye injury. His practice participation is a promising long-term sign.
49ers Also Battle Injuries Ahead of High-Stakes Primetime Game
San Francisco enters the game with its own injury concerns. Starting cornerback Renardo Green has been ruled out with a neck issue. Rookie wide receiver Ricky Pearsall will also miss the game.
Defensive lineman Yetur Gross-Matos is questionable with a hamstring injury. His potential return could boost the 49ers’ pass rush. The status of these players shapes Kyle Shanahan’s game plan.
The loss of Green tests San Francisco’s secondary depth. This could be an area the Colts’ offense looks to exploit on Monday night.
The final Colts injury report underscores the challenge ahead. A depleted defense must find a way to contain a powerful 49ers offense. This Monday Night Football game is a critical test for Indianapolis’s remaining postseason aspirations.
A quick knowledge drop for you:
Is DeForest Buckner playing against the 49ers?
DeForest Buckner is officially listed as questionable for Monday night. He did not practice due to a neck issue and for rest. His game-time decision is crucial for the Colts’ defensive line.
Who is out for the Colts in Week 16?
Cornerback Sauce Gardner and receiver Anthony Gould are officially out. Safety Daniel Scott is also ruled out despite a full week of practice. Their absences create depth challenges.
What is Anthony Richardson’s status?
Anthony Richardson Sr. returned to practice from Injured Reserve. He is recovering from a fractured orbital bone. He remains on IR and will not play Monday.
How do these injuries affect the game?
Missing Gardner weakens the pass defense against Brock Purdy. Buckner’s potential absence hurts the interior pass rush. The Colts’ defense faces a tougher task without its stars.
Are any key 49ers players injured?
Yes. Cornerback Renardo Green and receiver Ricky Pearsall are out. Defensive lineman Yetur Gross-Matos is questionable. The 49ers are also missing several contributors.
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