General Hospital Spoilers: Anna Faces Deadly Danger as Mystery Attacker Strikes on November 5

General Hospital spoilers for Wednesday, November 5, 2025, reveal that Anna Devane faces a terrifying situation as a mysterious figure closes in on her. The longtime WSB agent feels uneasy after a shocking chain of events in Port Charles, and her instincts prove right — danger is closer than ever.

Meanwhile, Sonny Corinthos arranges a private meeting with Justine, while other familiar faces find themselves caught in emotional crossroads. Here’s everything we know about what’s coming up on GH this week.

Anna Devane’s Nightmare: A Shadow From the Past Returns

Anna (Finola Hughes) is known for her intuition, and this week it’s on high alert. She confides in Jason (Steve Burton) that she senses something wrong about Britt (Kelly Thiebaud) and Nathan’s (Ryan Paevey) shocking return from the dead. The storyline takes a dark turn when she begins to suspect that the resurrected pair may be connected to the notorious Caesar Faison.

Determined to get answers, Anna starts investigating again — but she may not live to uncover the truth. In a tense scene teased in the GH promo, Anna is seen walking to her car when a gloved stranger sneaks up behind her and chloroforms her. The attack confirms that her fears weren’t paranoia — someone wants her silenced.

Whether this mysterious kidnapper is linked to Faison or a new enemy remains to be seen. Longtime fans know Faison’s history of manipulation runs deep, and his legacy has haunted Anna for decades. Now, her disappearance could shake Port Charles to its core.

Sonny, Gio, and More: Tensions Rise Across Port Charles

Elsewhere in Port Charles, Sonny (Maurice Benard) takes matters into his own hands. He arranges a private meeting with Justine (Nazneen Contractor), though the reason behind it remains a mystery. Given Sonny’s world of hidden agendas and uneasy alliances, fans can expect the meeting to have major consequences.

Meanwhile, Gio (Giovanni Mazza) continues to play the role of peacemaker, offering level-headed advice amid growing tensions. Alexis (Nancy Lee Grahn) shows her support for Danny (Asher Antonyzyn), helping him navigate a difficult emotional period.

At Bobbie’s, Felicia (Kristina Wagner) and Spinelli (Bradford Anderson) sit down with Nathan to discuss his sudden return and how it affects James (Gary James Fuller). While Nathan grows defensive, the conversation ends on a hopeful note — at least for now. But the peace might not last as questions about his reappearance continue to swirl.

The Road Ahead: What’s Next for General Hospital?

With Anna missing and Sonny making secretive moves, General Hospital appears to be building toward another explosive arc. The mystery surrounding Britt and Nathan’s return — and the possibility of Faison’s involvement — could tie multiple storylines together in a shocking reveal.

As the week unfolds, viewers can expect more twists, reunions, and emotional confrontations that redefine Port Charles alliances. Fans will be left asking the same question: who kidnapped Anna, and why?

General Hospital spoilers for November 5 confirm that danger looms over Anna, Sonny’s plans deepen, and a chilling mystery begins to unravel — one that could change everything.

FYI (keeping you in the loop)-

Q1: What happens to Anna on General Hospital on November 5?

Anna gets chloroformed by a mystery figure, leading to fears that she’s been kidnapped. Her fate remains unknown.

Q2: Who might be behind Anna’s attack?

Fans speculate that Caesar Faison or someone working under him could be behind the assault, though it’s not yet confirmed.

Q3: What is Sonny planning with Justine?

Sonny’s private meeting with Justine hints at secret business or protection matters, but details remain under wraps.

Q4: Are Britt and Nathan really alive?

Their sudden reappearance raises questions about whether they’re truly alive or part of a deeper deception.

Q5: What else happens in Port Charles this week?

Felicia and Spinelli meet Nathan, Alexis supports Danny, and Gio serves as the voice of reason amid chaos.