Jesse Williams is returning to Grey Sloan Memorial Hospital. The actor will reprise his role as Dr. Jackson Avery for an upcoming episode.

His unexpected appearance was revealed in a promotional teaser. This marks one of his few returns since his character’s departure in 2021.
Jackson Avery Pushes Meredith Back to Alzheimer’s Research
In the teaser, Jackson confronts Meredith Grey about her stalled work. He notes her lab in Boston sits completely unused. This prompts a tense exchange between the former colleagues.
Meredith expresses shock at his sudden presence. She also questions published research from another departed doctor. Jackson remains unfazed and challenges her to resume her important project.
This storyline continues Meredith’s pursuit of an Alzheimer’s cure. According to ABC, the show continues to blend medical drama with personal journeys. The interaction suggests a significant plot development for season 22.
Return Follows Other Major Character Surprises
Williams’ cameo follows another surprising return. Sophia Bush recently reprised her role as Dr. Cassie Beckham. Her character is now romantically involved with Dr. Teddy Altman.
These guest appearances signal a trend for the new season. The show is bringing back familiar faces to create new dynamics. This strategy often generates significant fan excitement and media coverage.
The upcoming episode also features other key developments. Dr. Atticus “Link” Lincoln is shown recovering from last season’s explosion. Multiple storylines are advancing simultaneously.
The return of Jesse Williams underscores the enduring appeal of Grey’s Anatomy legacy characters. His surprise cameo is sure to excite long-time viewers of the record-breaking medical drama.
Thought you’d like to know-
Why did Jesse Williams originally leave Grey’s Anatomy?
Jesse Williams departed the show in 2021 after 12 seasons. He decided to pursue other acting and directing opportunities. His character moved to Boston to run the Fox Foundation.
How many episodes will Jesse Williams appear in?
His current return appears to be for a single episode. The teaser specifically promotes the upcoming October 30th installment. Future appearances beyond this episode remain unconfirmed.
What is the status of Meredith’s Alzheimer’s research?
Meredith resumed her Alzheimer’s research project in season 19. Jackson’s comments indicate her work has recently stalled. This storyline connects back to her mother’s legacy and the show’s long-term narrative.
Are other original characters returning this season?
The season has already featured several returning actors. The production has not announced any other major comebacks. The show frequently surprises viewers with unexpected guest appearances.
When did Jackson Avery first appear on the show?
Jackson was introduced in season six as a Mercy West merger intern. He is the grandson of founding Harper Avery. The character became a series regular and fan favorite.
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