Jacksonville Jaguars vs. Arizona Cardinals Prediction: TV Channel, Live Stream, Kickoff Time and Week 12 Preview

The Jacksonville Jaguars vs. Arizona Cardinals prediction takes center stage as both teams meet in a crucial Week 12 matchup on Sunday. The game kicks off at 1 p.m. ET at All State Stadium, with playoff implications on the line for Jacksonville. The Cardinals return home searching for stability after two blowout losses.

The Jaguars enter the week at 6–4 and still in the AFC South race. Arizona continues to rely on Jacoby Brissett as injuries mount across the offense. Both teams hope this matchup sets a new tone heading into December.

How Jaguars vs. Cardinals Shapes Up in Week 12

The Jaguars begin Week 12 with a strong run game and a defense capable of creating turnovers. Liam Coen’s team averages 24.0 points per game and leans on Travis Etienne Jr. and Bhayshul Tuten for consistent production. Jacksonville’s pass attack is thin again with Brian Thomas Jr. out, but Trevor Lawrence gains a possible boost if tight end Brenton Strange returns.

Jacksonville’s defense remains steady. The unit allows 22.6 points per game and stops the run well. The challenge comes through the air, where injuries continue to affect the secondary. The pass rush ranks near the bottom of the league, making turnovers a key path to victory.

Arizona enters the week at 3–7 after back-to-back difficult losses. Brissett has thrown efficiently and even set a completions record last week, but the Cardinals lack consistency. With Marvin Harrison Jr. sidelined, Trey McBride becomes the central weapon, and his volume continues to rise.

The Cardinals average 22.4 points per game but struggle to run the ball. Their defense gives up 25.6 points per contest and has trouble generating pressure. The matchup becomes a test of discipline and execution, especially against Jacksonville’s run game.

Game Preview and Prediction for Jaguars vs. Cardinals

Trusted outlets like the Associated Press and Reuters have highlighted Jacksonville’s recent improvement in physicality and preparation. That trend must continue against a Cardinals team that throws more than any other offense in recent weeks. Arizona will again lean on McBride, Trey Benson’s backups, and Brissett’s ability to push the ball downfield.

For Jacksonville, establishing the run remains the easiest path forward. Arizona ranks 16th in opponent rushing yards but struggles in defensive efficiency. Coen’s offense has two productive backs and a steady offensive line. If the Jaguars win the time-of-possession battle and avoid turnovers, they control the matchup.

Arizona’s chance comes through an aggressive passing plan. Jacksonville’s secondary gives up yardage, and McBride’s production trends upward. Quick drives, tempo changes, and red-zone efficiency will be essential. Limiting big plays from Etienne and Tuten will also be key.

Overall, Jacksonville is better positioned due to their run game and turnover advantage. Arizona plays better at home, but the inconsistency makes them difficult to trust after back-to-back losses. Expect a competitive matchup early, with Jacksonville’s ground attack making the difference late.

Final Prediction: Jacksonville Jaguars 27, Arizona Cardinals 23.

FYI (keeping you in the loop)-

Q1: What time is the Jaguars vs. Cardinals game?

The game starts at 1 p.m. ET on Sunday. It will be played at All State Stadium. Local and national broadcasts will carry the matchup.

Q2: How can I watch the Jaguars vs. Cardinals live?

The game airs on CBS and Jaguars TV affiliates. Radio coverage is available on WJXL 1010AM/92.5 FM and Cardinals radio partners.

Q3: What is the latest Jaguars vs. Cardinals prediction?

Jacksonville enters as the more complete team thanks to their run game. Arizona’s passing attack keeps it close, but the Jaguars have the edge.

Q4: Which players are key to watch in Week 12?

Travis Etienne Jr., Bhayshul Tuten, Trevor Lawrence, and Trey McBride headline the matchup. Injuries may affect several positional groups.

Q5: Why is this game important for Jacksonville?

The Jaguars remain in the AFC South race. A Week 12 win strengthens their path toward a potential Wild Card push.