Kansas City Chiefs at Denver Broncos Prediction, TV Channel, Live Stream, Kickoff Time, Where to Watch and NFL Game Preview

The Kansas City Chiefs face the Denver Broncos in Week 11 on Sunday, November 16, 2025, at 4:25 p.m. ET at Empower Field at Mile High. This AFC West matchup could mark a pivotal shift in the division, with Denver looking to dethrone Kansas City after nearly a decade of dominance. The game will air live on CBS.

The Broncos enter at 8-2, leading the AFC West, while the Chiefs sit at 5-4 following a bye week. A Denver win could push them closer to securing their first division title since 2015. Meanwhile, Kansas City is fighting to stay in the playoff race and regain control of the division.

Chiefs vs Broncos Key Matchup Preview

Patrick Mahomes and the Chiefs have owned the AFC West, winning nine straight division titles. However, Denver’s resurgence behind rookie quarterback Bo Nix has changed the tone. The Broncos have won seven straight games and boast one of the league’s top defenses, allowing just 17.3 points per game (third-best in the NFL).

Mahomes has dominated Denver historically, winning 13 of 14 career meetings while averaging 269 passing yards per game. Yet, this season, Kansas City has struggled against top teams, losing four of five against winning opponents. Mahomes’ chemistry with Travis Kelce and Rashee Rice will be key to overcoming a Broncos pass rush that ranks among the NFL’s best.

Denver’s defense is led by Nik Bonitto, who ranks third in the NFL with 9.5 sacks. The team’s aggressive front has a league-best +35 sack differential through 10 games. Offensively, Bo Nix has 18 touchdown passes and just eight interceptions. His ability to stay composed against a battle-tested Chiefs defense could define the outcome.

Game Details and Predictions

Kickoff Time: 4:25 p.m. ET, Sunday, November 16, 2025
Location: Empower Field at Mile High, Denver, Colorado
TV Channel: CBS
Live Stream: Available via CBS Sports and NFL platforms

Oddsmakers slightly favor Kansas City at -4.5, with an over/under of 45.5 points. Analysts project a close, high-energy game where Kansas City’s experience could prevail. Mahomes and head coach Andy Reid have been here before — facing adversity midseason — and typically rise when challenged.

Still, Denver’s home-field advantage and balance on both sides of the ball make this a dangerous test for the defending champions. Expect the Broncos to play aggressively, relying on Nix, wideout Troy Franklin, and running back RJ Harvey to keep drives alive against a top-10 Kansas City defense.

What to Expect from Both Teams

Kansas City’s offense ranks seventh in total yards (370.1 per game), while their defense allows just 291.8 yards, ranking sixth. The return of Kareem Hunt adds another dimension to their red-zone offense, as he’s scored in four of his last five games.

Denver ranks ninth in rushing yards (128.6 per game) and fourth in rushing defense (91.2 yards allowed). Their young core — Nix, Franklin, and Harvey — gives them versatility and potential for explosive plays. If they can limit turnovers and pressure Mahomes, the Broncos could deliver a statement win that signals a true power shift in the AFC West.

Prediction: Chiefs 27, Broncos 23. Kansas City’s experience and Mahomes’ composure in clutch moments may ultimately prove the difference in another thrilling AFC West battle.

FYI (keeping you in the loop)-

Q1: What time is the Kansas City Chiefs vs Denver Broncos game?

The game kicks off at 4:25 p.m. ET on Sunday, November 16, 2025.

Q2: Where can I watch the Chiefs vs Broncos game?

The game will air on CBS and can be streamed through CBS Sports and NFL platforms.

Q3: What is the Kansas City Chiefs at Denver Broncos prediction?

Experts predict a close contest with Kansas City winning 27-23, led by Patrick Mahomes’ experience.

Q4: How have the Broncos performed at home?

Denver has won 10 consecutive home games, showing strong consistency at Mile High.

Q5: What is the betting line for the Chiefs vs Broncos?

Kansas City is favored by 4.5 points, with an over/under total of 45.5 points.