Kyler Murray Injury Update: Will Cardinals QB Miss More Games After Foot Setback?

Arizona Cardinals quarterback Kyler Murray will sit out his second straight game due to a lingering foot injury, raising questions about how long the former No. 1 pick could remain sidelined. The Cardinals confirmed on Sunday that Murray was placed on the inactive list ahead of their Week 7 matchup against the Green Bay Packers.

The 28-year-old was first injured during the third quarter of Arizona’s October 5 loss to the Tennessee Titans. After being listed as limited in practice last week, hopes rose that he might return for Week 7. However, head coach Jonathan Gannon stressed that Murray will only play when he is “fully healthy,” suggesting the team won’t take any risks with its franchise quarterback.

Brissett Steps In as Starter Again

Veteran Jacoby Brissett started in Murray’s place last week against the Indianapolis Colts and will lead the offense again versus Green Bay. In his first start, Brissett went 27-of-44 for 320 yards, two touchdowns, and one interception. Despite the loss, the veteran showed he can move the offense and keep the team competitive.

Arizona enters Week 7 with a 2-4 record, looking to stay afloat in a tough NFC West. Facing a Packers team that sits at 3-1-1, the Cardinals need stability from their backup as Murray continues to recover.

Injury Concerns Beyond Murray

The Cardinals’ injury list remains long. Rookie wide receiver Marvin Harrison Jr. is still in concussion protocol. Running back Emari Demercado (ankle) and wide receiver Zay Jones (knee) also missed practice time. Several defensive players, including linebacker Akeem Davis-Gaither (foot) and cornerback Darren Hall (quadriceps), were listed as limited participants.

One positive update came with the activation of rookie defensive lineman Walter Nolen III’s 21-day practice window. The No. 16 overall pick in the 2025 NFL Draft had been sidelined since training camp with a calf injury.

What Murray’s Absence Means for the Cardinals

Murray’s injury is especially concerning given his history. He missed most of the 2022 season and the first nine weeks of 2023 while recovering from a torn ACL. His return had brought renewed hope for the franchise, but his current setback raises questions about his durability long-term.

Before the injury, Murray was performing at a high level. In five starts this season, he completed 68.3% of his passes for 962 yards, six touchdowns, and three interceptions. He also rushed for 173 yards and a touchdown, reaffirming his reputation as one of the league’s most dangerous dual-threat quarterbacks.

For now, Arizona is taking a cautious approach. The team has not provided a specific timetable for his return, leaving fans to wonder whether Murray will miss more than just two games. With their playoff hopes still alive, the Cardinals need their star quarterback back — but not at the cost of further injury.

Kyler Murray’s foot setback puts the spotlight on his recovery timeline. As the Cardinals weigh risk against reward, the uncertainty leaves fans asking: when will their franchise QB finally return?

FYI (keeping you in the loop)-

Q1: What is the current Kyler Murray injury status?

He has been ruled out for Week 7 with a foot injury, missing his second straight game.

Q2: Who is starting for the Cardinals instead of Murray?

Jacoby Brissett will start at quarterback against the Green Bay Packers.

Q3: How long has Murray been sidelined?

He has missed two games since being injured against the Titans on October 5.

Q4: What are Murray’s 2025 season stats so far?

He has 962 passing yards, six touchdowns, three interceptions, plus 173 rushing yards and one rushing score.

Q5: Could Murray miss more games?

The team has not given a timeline. His return depends on when he is fully healthy.