Memory of a Killer Trailer Unveils Patrick Dempsey’s High-Stakes TV Return

Fox has released the first official trailer for its new drama series, “Memory of a Killer.” The series stars Patrick Dempsey as a hitman battling early-onset Alzheimer’s disease. It is set to premiere on January 26, 2026.

The trailer confirms Dempsey’s major return to broadcast television. It reveals a tense, character-driven thriller based on a renowned European film.

Dempsey Leads a Morally Complex New Drama for Fox

Patrick Dempsey plays Angelo Doyle, a professional assassin leading a double life. He is a devoted father by day and a lethal contractor by night. His world fractures after a shocking medical diagnosis.

Angelo is diagnosed with early-onset Alzheimer’s. The condition makes his dangerous work nearly impossible. According to reports from Deadline, it also triggers a long-buried conscience.

The central plot ignites when his pregnant daughter, Maria, becomes a target. Angelo must find who is threatening her while his own memory fails. He also suspects his wife’s recent death was not an accident.

This forces him to merge his two separate identities. He becomes a hunter protecting his last family member. The series explores redemption through irreversible loss.

A Premium Ensemble Cast Joins the Hunt

The cast features several notable names alongside Dempsey. Gina Torres plays FBI Special Agent Linda Grant, who is pursuing the truth. Michael Imperioli appears as Dutch, Angelo’s friend with criminal ties.

Odeya Rush takes the role of Maria, the daughter in peril. Richard Harmon plays Joe, a fellow hitman within the story’s underworld. The ensemble adds depth to the high-concept premise.

Fox and producer Warner Bros. Television are betting on serious drama. The project is adapted from the acclaimed 2003 Belgian film “The Alzheimer Case.” This source material was a critical success in Europe.

The adaptation expands the film’s story for a serialized format. It aims to blend family drama with tense crime thriller elements. The show enters a competitive winter television landscape.

The “Memory of a Killer” trailer promises a unique and gripping psychological drama. It marks a significant shift in programming for Fox. Audiences can expect a high-stakes story when it premieres next year.

Dropping this nugget your way-

What is “Memory of a Killer” about?

It follows hitman Angelo Doyle, played by Patrick Dempsey. He struggles with early-onset Alzheimer’s while trying to protect his daughter. His failing memory and resurging conscience create intense conflict.

When does the series premiere?

The show premieres on Fox on January 26, 2026. It will air at 9 p.m. EST. The first trailer was released in late 2025.

Who else is in the cast?

Gina Torres plays an FBI agent. Michael Imperioli and Odeya Rush have key supporting roles. The cast adds significant dramatic weight to the concept.

Is this based on another story?

Yes. It is adapted from the 2003 Belgian film “The Alzheimer Case.” That film earned international praise for its original take on the premise.

Why is this a notable role for Patrick Dempsey?

It marks his leading return to broadcast network television. He is known for “Grey’s Anatomy” but takes on a darker, more complex character here. It shows a new direction for his career.

What is the main conflict in the story?

The core conflict is Angelo’s fight to protect his family as his mind deteriorates. He must solve a personal mystery while evading the law and his employers. His disease is both a liability and a catalyst for change.