Michigan vs. Oklahoma Prediction and Start Time for Week 2 Clash

Michigan and Oklahoma meet on Saturday, September 6, 2025, in a primetime Week 2 college football showdown. The game will kick off at 7:30 p.m. ET at Gaylord Family Oklahoma Memorial Stadium in Norman. Oklahoma enters the matchup as the betting favorite after a dominant Week 1 win. Michigan brings a true freshman quarterback into one of the toughest road tests in the country.

The matchup is a spotlight game for both programs. Michigan is pushing to return to the College Football Playoff after missing out last year. Oklahoma is trying to prove it can contend in the SEC after back-to-back losing seasons. Both teams rely on strong defenses, making this one of the most anticipated games of the weekend.

Michigan vs. Oklahoma Prediction and Odds

According to major betting markets, Oklahoma is favored by 5 points. The over/under is set near 44.5, signaling a low-scoring battle. Computer models project the Sooners as the more likely winner, with about a 60% chance to win. A common projected score is Oklahoma 24, Michigan 21.

Oklahoma’s new quarterback John Mateer impressed last week, throwing for nearly 400 yards against Illinois State. His quick start has raised hopes for a more explosive offense. On the other side, Michigan freshman Bryce Underwood was sharp in his debut win over New Mexico. This game will test his poise against a top SEC defense.

Both defenses are loaded. Michigan’s defensive front will challenge Oklahoma’s offensive line. The Sooners will try to contain Michigan’s powerful running backs Jordan Marshall and Justice Haynes. The team that wins the turnover battle is likely to walk away with the victory.

Key Storylines to Watch

Michigan’s rookie quarterback is under the spotlight. Underwood has the talent, but playing at night in Norman is a different challenge. If Michigan can establish the run, the pressure on him will ease.

Oklahoma’s offense looks new under coordinator Ben Arbuckle. The Sooners added transfers to boost their wide receiver group, and Mateer showed chemistry in his first start. Keeping drives alive against Michigan’s defense will be critical.

History favors Oklahoma. The Sooners beat Michigan in their only meeting back in 1976, the same season they claimed a national title. The Wolverines aim to even the series this time.

Both teams need this win for momentum. Michigan has a Big Ten schedule ahead, while Oklahoma will soon face Auburn and Texas. A victory here builds confidence for the season’s toughest tests.

Final Score Prediction: Oklahoma 24, Michigan 20
The defenses will control the pace. Oklahoma has the slight edge at home, but Michigan should cover the spread. Expect a tight, physical game from start to finish.

FYI (keeping you in the loop)-

Q1: What time does Michigan vs. Oklahoma start?

The game starts at 7:30 p.m. ET on Saturday, September 6, 2025, in Norman, Oklahoma.

Q2: Who is favored to win between Michigan and Oklahoma?

Oklahoma is favored by about 5 points, with most models giving them a 60% chance to win.

Q3: How did Michigan perform in Week 1?

Michigan beat New Mexico 34-17. Freshman quarterback Bryce Underwood passed for 251 yards in his debut.

Q4: How did Oklahoma perform in Week 1?

Oklahoma crushed Illinois State 35-3. Quarterback John Mateer threw for 392 yards and 3 touchdowns.

Q5: What is the predicted final score?

Most predictions have Oklahoma winning 24-20 in a close defensive game.