NFL Injury Update: Latest Week 12 News on Josh Jacobs, Drake London and Key Fantasy Stars

The NFL injury landscape has shifted again heading into Week 12, and several major fantasy football contributors are uncertain for Sunday. This NFL injury update highlights the latest on Josh Jacobs, Drake London, Michael Penix Jr., Aaron Rodgers and more. The list includes confirmed diagnoses, team statements and what managers should expect for the upcoming slate.

Week 11 brought multiple setbacks across the league. Several playmakers left their games early, while others moved to injured reserve. The updates this week will affect start/sit decisions, waiver priorities and lineup planning as fantasy managers push toward the playoffs.

Week 12 Injury Developments Across Key NFL Offenses

Josh Jacobs avoided a major knee injury, according to reporting from NFL Network, and imaging showed his knee is structurally sound. The Packers running back is considered day-to-day, but his Week 12 status remains uncertain. If he cannot go, Emanuel Wilson is expected to lead the backfield with Chris Brooks also in the mix.

Atlanta faces a tougher situation. Michael Penix Jr. suffered a knee injury in Week 11 and is reportedly headed to injured reserve, as noted by ESPN. Kirk Cousins would start in his absence, which lowers the ceiling of the entire passing game. The Falcons also lost star wideout Drake London to a PCL sprain. Head coach Raheem Morris confirmed that London is week-to-week. He will miss Week 12 against the Saints and could be out longer. Darnell Mooney becomes the primary beneficiary, and Kyle Pitts Sr. may see increased work.

Pittsburgh’s quarterback situation is also in flux. Aaron Rodgers exited with a wrist fracture but avoided surgery. He is pushing to play in Week 12, though head coach Mike Tomlin told reporters that his status is uncertain. Jaylen Warren, who injured his ankle, is trending in a more positive direction. Tomlin said he is optimistic Warren will be available Sunday, but if he is limited, Kenneth Gainwell becomes a valuable waiver option.

Jacksonville rookie Bhayshul Tuten was impressive before leaving with an ankle issue. Travis Etienne Jr. handled the bulk of touches afterward, while LeQuint Allen Jr. worked late in the game. If Tuten misses Week 12, Allen should see a larger role behind Etienne, especially as the Jaguars lean more on their ground game.

Giants quarterback Jaxson Dart remains in concussion protocol. If he is cleared later this week, New York may limit designed runs to protect their rookie starter. In Tennessee, Calvin Ridley suffered a fractured fibula and is out for the season, head coach Mike McCoy confirmed. Rookie Elic Ayomanor steps in as the top option, but the Titans remain one of the least reliable passing teams for fantasy purposes.

Houston quarterback C.J. Stroud practiced Tuesday but is not expected to clear concussion protocol in time for Thursday Night Football, according to ESPN. Davis Mills will make his third straight start against the Bills.

How These Week 12 Injuries Shape Fantasy Football Outlooks

These injuries affect nearly every position in fantasy football. Jacobs’ availability could swing matchups, especially with Green Bay facing a physical Minnesota defense. London’s absence is one of the biggest blows of the week, as he has averaged more than 16 fantasy points per game. Managers may need to rely on streaming receivers or lower-rostered options.

Penix landing on injured reserve resets the outlook for the entire Falcons offense. Cousins brings experience but less mobility, which could lead to a heavier workload for Bijan Robinson. Meanwhile, Rodgers’ wrist injury raises questions for Pittsburgh’s offense, but the Steelers may lean heavily on their run game regardless of who starts.

For deeper leagues, players like Allen, Mooney, and Gainwell become meaningful adds. The fantasy football playoff window is tightening, making each injury decision more impactful.

As Week 12 approaches, this NFL injury update outlines several key situations that will shape roster decisions. With playoffs looming, managers must stay aware of last-minute status shifts and depth chart changes to stay competitive.

FYI (keeping you in the loop)-

Q1: Is Josh Jacobs playing in Week 12?

Jacobs is day-to-day with a knee injury. The Packers have not ruled him out, but his status will likely come down to practice participation.

Q2: How long will Drake London be out?

London is out for Week 12 with a PCL sprain. He is officially week-to-week and may miss additional games.

Q3: Who replaces Michael Penix Jr. for the Falcons?

Kirk Cousins will start while Penix is on injured reserve. The Falcons may shift toward a run-heavy approach.

Q4: Should fantasy managers add Kenneth Gainwell?

Gainwell is a strong add if Jaylen Warren is limited. He handled work late in Week 11 and has RB2 upside if Warren sits.

Q5: Is C.J. Stroud returning this week?

No. Stroud has not cleared concussion protocol and will miss Thursday Night Football. Davis Mills will start again.