NFL Week 1 Injury Report: Key Players Sidelined Across the League

The NFL’s 2025 season kicked off with intense action and significant injuries. Several star players left games early, creating immediate challenges for their teams. This wave of injuries is impacting team strategies for the upcoming weeks.

According to official NFL reports, multiple teams are evaluating key contributors. The first week has already tested the depth of numerous franchises.

Impact on Team Rosters and Season Outlook

High-profile names headline the Week 1 injury list. The Los Angeles Rams’ wide receiver Puka Nacua underwent concussion evaluation against the Houston Texans. His status is critical for the Rams’ offensive plans.

The San Francisco 49ers also faced setbacks. Tight end George Kittle sustained a hamstring injury versus the Seattle Seahawks. His absence would be a major blow to their passing attack. These early injuries force teams to rely on their backups immediately.

Evaluating the Broader League-Wide Consequences

Injuries are an unavoidable part of the sport, but their concentration in Week 1 is notable. Teams with thin depth charts face an uphill battle. This situation often leads to increased activity in the free-agent market.

Fans and analysts will watch how teams adapt. The ability to overcome these early losses often defines a season’s trajectory. The physical toll of Week 1 underscores the league’s demanding nature.

The high volume of NFL Week 1 injuries has immediately reshaped the competitive landscape, proving that depth is as valuable as star power in the long NFL season.

Info at your fingertips

Which star players were injured in NFL Week 1?

Notable injuries include Puka Nacua (Rams) being evaluated for a concussion and George Kittle (49ers) with a hamstring issue. Falcons receiver Drake London also suffered a shoulder sprain.

How do teams handle these sudden player losses?

Teams immediately turn to their backup players on the roster. They may also sign free agents or promote practice squad members to fill the gaps on the depth chart.

Are concussion protocols different this season?

The NFL’s concussion protocol remains a strict multi-step process. It mandates that a player must be cleared by an independent neurologist before returning to game action.

Which team was most affected by injuries in Week 1?

Several teams, including the Green Bay Packers and Miami Dolphins, reported multiple injuries to key positional groups. The full impact will become clearer as official status reports are released.