The opening betting lines for NFL Week 10 are now live. This comes as the final games of Week 9 conclude. Odds are available on major sportsbooks like DraftKings. The new slate features several compelling divisional matchups.

Week 10 action kicks off with a Thursday night game. It continues with 12 Sunday contests and a Monday night finale. One game will be played in Berlin, Germany, as part of the NFL’s international series.
Analyzing the Week 10 NFL Odds Board
According to data from ESPN, the week starts with the Las Vegas Raiders visiting the Denver Broncos. Denver is a heavy home favorite. The Broncos are currently listed at -9.5 points on the spread.
Sunday features a key AFC East battle. The Buffalo Bills are significant road favorites against the Miami Dolphins. The Bills are giving 9.5 points in that matchup.
Another notable game sees the Baltimore Ravens favored against the Minnesota Vikings. Lamar Jackson’s health has been a positive factor for Baltimore. The Ravens are a 3.5-point favorite in early lines.
Key Storylines and Betting Implications
Injuries are already influencing the Week 10 lines. The Houston Texans may be without quarterback C.J. Stroud. This has affected their status as a slight favorite over the Jacksonville Jaguars.
The international game in Berlin adds another layer. The Atlanta Falcons face the Indianapolis Colts early Sunday. Teams often face unique challenges with travel and time zones.
The Sunday night game pits the Pittsburgh Steelers against the Los Angeles Chargers. The Chargers are a 3-point home favorite. Both teams are fighting for playoff positioning in their respective conferences.
The full NFL Week 10 odds provide the first glimpse into how bookmakers view the evolving league landscape, with several games already drawing significant early attention from analysts.
Dropping this nugget your way
What is the biggest point spread for NFL Week 10?
The largest spread is for the Buffalo Bills at Miami Dolphins game. The Bills are currently favored by 9.5 points. This indicates a strong expectation for a Buffalo victory.
Which teams are on a bye in Week 10?
Four teams will not play in Week 10. The Cincinnati Bengals, Dallas Cowboys, Kansas City Chiefs, and Tennessee Titans all have byes. This reduces the total number of games for the week.
Where is the NFL international game in Week 10?
The Atlanta Falcons and Indianapolis Colts will play in Berlin, Germany. The game is scheduled for a 9:30 a.m. ET kickoff on Sunday. This is part of the NFL’s ongoing effort to grow the game globally.
Who is favored in the Monday Night Football game?
The Green Bay Packers are early favorites over the Philadelphia Eagles. The Packers are giving 2.5 points at home. The Eagles are coming off their bye week.
Why are the Houston Texans only slight favorites?
Starting quarterback C.J. Stroud is in the concussion protocol. His potential absence creates uncertainty for the Texans’ offense. This has made the line much closer against the Jacksonville Jaguars.
iNews covers the latest and most impactful stories across
entertainment,
business,
sports,
politics, and
technology,
from AI breakthroughs to major global developments. Stay updated with the trends shaping our world. For news tips, editorial feedback, or professional inquiries, please email us at
[email protected].
Get the latest news first by following us on
Google News,
Twitter,
Facebook,
Telegram
, and subscribe to our
YouTube channel.



