NFL Week 11 Injury Update: Key Status Changes for Bucky Irving, Davante Adams and Brock Purdy

The NFL Week 11 injury update brings several major developments as teams finalize their game-day statuses. Key names such as Bucky Irving, Davante Adams and Brock Purdy headline this week’s reports. Many teams enter the weekend without essential starters, raising questions about depth, performance and late-season momentum.

Week 11 features critical matchups across both conferences, and injuries could shift outcomes. Multiple teams released long lists of unavailable players, while others welcome important returns. Officials and team staff across the league confirmed most designations on Friday, giving fans a clearer picture before kickoffs on Sunday and Monday.

Major Week 11 Injury Highlights Across the League

The Tampa Bay Buccaneers will again be without rookie running back Bucky Irving, who is sidelined because of foot and shoulder issues. He was limited at practice throughout the week but did not progress enough for clearance. The Buccaneers also ruled out Chris Godwin Jr., Ben Bredeson and Haason Reddick, leaving several holes on offense and defense.

For the Los Angeles Rams, star wideout Davante Adams is listed as questionable with an oblique injury. Coach Sean McVay said Friday that Adams is expected to play, though his workload may be monitored. Kobie Turner also carries a questionable tag but is trending toward availability.

The San Francisco 49ers confirmed the return of quarterback Brock Purdy, who missed most of the year with a toe injury. Purdy practiced fully and carries no game-day designation. His return comes as the 49ers travel to face Arizona, a roster significantly weakened this week. The Cardinals ruled out multiple starters, including Marvin Harrison Jr., who underwent appendicitis surgery.

Houston will not have C.J. Stroud again due to a concussion. Davis Mills will make another start. The Texans also ruled out safety Jalen Pitre and kicker Ka’imi Fairbairn. Tennessee remains banged up as well, with Calvin Ridley and Jeffery Simmons listed as questionable.

The Cincinnati Bengals will once again be without quarterback Joe Burrow. He practiced for the first time in weeks but is not yet ready for activation. Joe Flacco will start, while Trey Hendrickson and Samaje Perine are also unavailable. The Steelers, meanwhile, ruled out Alex Highsmith and Darius Slay.

The Detroit Lions released one of the longest injury reports of Week 11. Sam LaPorta, Terrion Arnold and Kerby Joseph are out. Several linemen including Penei Sewell are questionable, raising concerns as they face Philadelphia. The Eagles list only one player on the report and appear close to full strength.

Across the early games, Washington ruled out Jayden Daniels and Terry McLaurin. Miami added Bradley Chubb late in the week as questionable. Minnesota will be without Jonathan Greenard and center Ryan Kelly. Green Bay ruled out Nate Hobbs, while the Giants will start Jameis Winston with Jaxson Dart out.

In the late-afternoon slate, Kansas City ruled out running back Isiah Pacheco, while Denver will not have J.K. Dobbins due to a serious foot injury. Baltimore expects Lamar Jackson to play after full practices. Cleveland may be without Maliek Collins, who was a late-week addition to the report.

How Week 11 Injuries Could Influence Key Matchups

The absence of Bucky Irving places added pressure on the Buccaneers’ young offense. Tampa Bay has struggled on the ground without him, and losing Godwin further stretches the passing game. The Bills, already dealing with defensive injuries, must adjust to a weakened secondary as Taron Johnson and Cam Lewis remain questionable.

The 49ers’ offense could immediately improve with Brock Purdy’s return. His timing with receivers and command of the system have been essential to San Francisco’s production. Facing an Arizona defense missing several starters may ease his transition back into action.

Davante Adams’ availability is important as the Rams push for midseason stability. A limited Adams still draws coverage and could change how Seattle schemes its secondary. Meanwhile, Joe Burrow’s continued absence limits Cincinnati’s offensive ceiling during a crucial AFC stretch.

The Lions’ injuries could affect both ends of their Sunday night matchup. Missing multiple defensive backs against Philadelphia’s passing attack poses a challenge. Their offensive line depth will also be tested if Sewell cannot suit up.

As Week 11 kicks off, the NFL injury landscape remains one of the biggest factors shaping matchups. Teams like the 49ers, Bills, Lions and Buccaneers will face major lineup questions as they navigate a crucial part of the season. This NFL Week 11 injury update reflects the latest official information before game day.

FYI (keeping you in the loop)-

Q1: Which players headline the NFL Week 11 injury update?

Bucky Irving, Davante Adams, Brock Purdy and Joe Burrow are among the biggest names. Many others across the league carry questionable or out designations.

Q2: Is Brock Purdy cleared to return?

Yes. The 49ers confirmed he carries no injury designation and will play in Week 11 after recovering from a toe injury.

Q3: Will Davante Adams play this week?

He is listed as questionable. Coach Sean McVay said Adams is expected to suit up barring setbacks.

Q4: Why is Bucky Irving out again?

He continues to deal with foot and shoulder injuries. Despite limited practices, he was not cleared for Week 11.

Q5: Which teams are most impacted in Week 11?

The Lions, Buccaneers, Texans, Bengals and Cardinals face major lineup losses due to injuries entering the weekend.