Nick Bosa Injury Update: 49ers Star DE Leaves Game vs Cardinals With Knee Issue

San Francisco 49ers star defender Nick Bosa suffered a knee injury during the team’s Week 3 game against the Arizona Cardinals. The five-time Pro Bowler exited in the second quarter after visiting the sideline medical tent. He was later seen walking back to the locker room with trainers while giving a thumbs down gesture to fans.

The 49ers have listed Bosa as questionable to return. His exit adds to a growing list of injuries for the team, including George Kittle, Brock Purdy, and Jauan Jennings. According to Reuters, the 49ers’ medical staff is continuing to evaluate the defensive end.

Nick Bosa Injury Update and What It Means for the 49ers

Nick Bosa entered the Cardinals game with two sacks in his first two outings of the 2025 season. His impact on San Francisco’s defensive line is undeniable. Losing him, even temporarily, would be a major setback for a defense built around his pass-rushing power.

The 49ers’ defense already faced pressure with key offensive names sidelined. Kittle has been nursing a hamstring injury, while quarterback Brock Purdy has been battling a toe issue. Jennings has also been limited by ankle and shoulder problems. With Bosa added to the list, San Francisco’s roster depth is being tested early.

On the depth chart, rookie Mykel Williams and Sam Okuayinonu are next in line to step up. Williams, the team’s first-round pick in the 2025 NFL Draft, has shown promise. Yet replacing Bosa’s production and leadership will not be simple.

How the Injury Impacts San Francisco’s Season Start

The 49ers opened the season strong but now face a test of resilience. Losing a player like Bosa shifts the pressure onto younger defenders and veterans alike. His knee injury also raises questions about San Francisco’s long-term defensive stability.

Injuries to top players have already forced changes in game planning. Without Bosa, the defensive line may struggle to apply the same level of pressure on opposing quarterbacks. This could put more responsibility on the secondary and linebackers.

For fans, the sight of Bosa leaving the field with a thumbs down gesture was alarming. The gesture suggests he was frustrated with the setback. The team and its supporters will now wait for further updates on the severity of his knee issue.

Nick Bosa remains the key to the 49ers’ defensive success. His injury update will shape the next stretch of the season. Fans and analysts alike will be watching closely for word on his recovery timeline.

FYI (keeping you in the loop)-

Q1: What happened to Nick Bosa in the Cardinals game?

Nick Bosa injured his knee in the second quarter. He left the field with trainers and did not return immediately.

Q2: Is Nick Bosa expected to miss games?

The 49ers have listed him as questionable. The team has not confirmed the length of his absence yet.

Q3: Who will replace Nick Bosa if he is out?

Mykel Williams and Sam Okuayinonu are next on the depth chart. Williams is a first-round rookie with high expectations.

Q4: How many injuries have the 49ers faced this season?

George Kittle, Brock Purdy, and Jauan Jennings are all dealing with injuries. Bosa’s setback adds to the list.

Q5: How important is Nick Bosa to the 49ers?

Bosa is the leader of the pass rush and a top playmaker. His absence would be a major blow to the defense.