Nick Bosa Injury Update: 49ers Star Out for Season After Torn ACL

San Francisco 49ers defensive end Nick Bosa has suffered a season-ending injury. The star pass-rusher tore his right ACL on Sunday. The injury came in the first quarter against the Arizona Cardinals. The team later confirmed the diagnosis.

This is a crushing blow for the 49ers. Bosa is a former Defensive Player of the Year and one of the most feared players in the NFL. He had already produced two sacks and eight quarterback pressures in the first two games. His absence will test the depth of the San Francisco defense.

Nick Bosa Injury Update and Its Immediate Impact

The 49ers lose their leader on defense. Bosa has been central to the team’s pass rush. His speed and strength often changed games. Against the Seahawks in Week 1, he forced a game-saving fumble. Without him, the defense will not look the same.

According to Reuters, the team now turns to rookie Mykel Williams and veteran Bryce Huff. Both will be asked to step up in larger roles. Left tackle Trent Williams admitted the loss is massive. He said the team would need multiple players to replace what Bosa brings on his own.

San Francisco is 3-0 after its narrow win over Arizona. But the road ahead is much tougher. The NFC West remains highly competitive. The Seattle Seahawks, who dominated the Saints on Sunday, now see an opening. The Week 18 clash between these rivals could decide the division.

How the 49ers Will Adjust Without Their Star Edge-Rusher

The team will need to rely on scheme and depth. Defensive coordinator plans may change. Blitz packages could increase. Linebackers and safeties may be used more aggressively.

But there is no easy fix. Bosa was more than a sack artist. He drew double-teams. He forced quarterbacks into mistakes. He gave teammates easier matchups.

For the Seahawks, this changes the outlook. Their offense now faces less pressure from the edge. The 12th man will feel the momentum shift. Still, San Francisco will fight to stay on top of the NFC West.

Nick Bosa injury update leaves the 49ers vulnerable in the playoff race. His season is over, but the impact of his absence is only beginning.

FYI (keeping you in the loop)-

Q1: What is the latest Nick Bosa injury update?

Nick Bosa tore the ACL in his right knee on Sunday. The injury will keep him out for the rest of the 2025 season.

Q2: How many games will Nick Bosa miss?

He is ruled out for the final 14 games of the regular season. He may also miss the playoffs if the 49ers qualify.

Q3: Who will replace Nick Bosa in the 49ers defense?

Rookie Mykel Williams and veteran Bryce Huff will see more snaps. The team may also rotate other players on the line.

Q4: How does this affect the NFC West race?

The Seattle Seahawks gain an edge in the division. Without Bosa, the 49ers defense may struggle to dominate key games.

Q5: Has Nick Bosa had major injuries before?

Yes. He tore his left ACL in 2020. This new injury is on the opposite knee, raising long-term concerns.

References

Reuters. (2025, September 22). San Francisco 49ers confirm Nick Bosa ACL tear.

Associated Press. (2025, September 22). 49ers lose defensive star to season-ending injury.

ESPN. (2025, September 22). Analysis of Bosa’s impact on San Francisco defense.