San Francisco 49ers @ Los Angeles Rams: Time, Predictions, and How to Watch Thursday Night Football

The San Francisco 49ers and Los Angeles Rams face off on Thursday, October 2, 2025, at SoFi Stadium in Los Angeles. Both teams enter Week 5 tied at 3-1, making this NFC West clash crucial for first place in the division. Kickoff is set for 8:15 p.m. ET (5:15 p.m. PT).

This matchup puts two of the NFC’s most competitive squads head-to-head under the Thursday Night Football spotlight. The 49ers’ strong defensive front and the Rams’ dynamic passing game set the stage for a high-stakes showdown that could shape the rest of the season.

49ers vs Rams Game Details and Broadcast Information

Thursday Night Football continues its exclusive run on Amazon Prime Video. Viewers can stream the game with a Prime membership ($15/month or $139/year) or a standalone Prime Video subscription ($9/month). NFL+ will also stream the game for mobile users. Coverage begins at 7 p.m. ET, with the official kickoff at 8:15 p.m. ET.

The 49ers come into the game with one of the league’s top defenses, anchored by Nick Bosa and Fred Warner. Quarterback Brock Purdy has managed the offense efficiently, connecting with key weapons like Deebo Samuel and Brandon Aiyuk. The Rams, meanwhile, look to Matthew Stafford’s arm and rookie sensation Puka Nacua to keep pace with the 49ers’ pass rush. Running back Kyren Williams adds balance to Los Angeles’ attack.

According to analysts at outlets like Reuters and the Associated Press, the winner of this game will gain an early edge in the NFC West race, especially with the Seattle Seahawks also in the hunt.

What to Expect From This NFC West Showdown

San Francisco has won four of its last five meetings with Los Angeles, but the Rams have shown they can score quickly when Stafford is healthy. Expect the 49ers to lean on their defensive front to pressure Stafford and control the tempo with their running game. Los Angeles will try to counter with deep shots and quick passes to avoid sacks and turnovers.

Both teams enter relatively healthy, but depth and discipline could decide the outcome. A 49ers win would cement them as early NFC favorites. A Rams victory would signal a potential power shift in the division.

This Thursday Night Football clash between the San Francisco 49ers and Los Angeles Rams promises a playoff-like atmosphere. Fans should expect a physical, fast-paced game with major division implications.

FYI (keeping you in the loop)-

Q1: What time is the San Francisco 49ers @ Los Angeles Rams game?

The game starts at 8:15 p.m. ET on Thursday, October 2, 2025, with coverage beginning at 7 p.m. ET.

Q2: How can I watch the 49ers vs Rams game tonight?

The game streams exclusively on Amazon Prime Video. NFL+ will also offer streaming on mobile devices.

Q3: Where is the 49ers vs Rams game being played?

The game takes place at SoFi Stadium in Inglewood, California.

Q4: Are the 49ers and Rams tied in their division?

Yes. Both teams enter Week 5 with a 3-1 record, tied for first place in the NFC West.

Q5: Who are the key players to watch in this game?

Brock Purdy and Nick Bosa for the 49ers; Matthew Stafford and Puka Nacua for the Rams.