San Francisco 49ers vs. Arizona Cardinals Prediction, TV Channel, Live Stream and Kickoff Details

The San Francisco 49ers face the Arizona Cardinals today, Sunday, Nov. 16, 2025, in a key NFC West matchup at State Farm Stadium in Glendale, Arizona. The game kicks off at 4:05 p.m. ET and will be broadcast live on FOX. Fans can also watch via several free streaming trials, including DIRECTV and FuboTV.

This game holds significant weight in the divisional race. The 49ers (6-4) are looking to bounce back from a tough 42-26 loss to the Rams, while the Cardinals (3-6) are trying to recover after a 44-22 defeat to Seattle. Both teams are battling injuries and playoff pressure as they meet for the second time this season.

How to Watch 49ers vs. Cardinals Live for Free

Viewers can stream the 49ers vs. Cardinals game live through several platforms offering limited-time free trials:

• DIRECTV Stream – 5-day free trial, includes FOX and regional sports networks.
• FuboTV – 5-day free trial, offers over 200 channels and up to $30 off for new users.
• Sling TV – No free trial, but has $30 off the first month for new users.
• NFL+ – Streams all local games live and provides access to game replays and coaches’ film.

Kickoff is at 4:05 p.m. ET, and fans can also listen via local radio affiliates or follow live updates across major sports networks. Both DIRECTV and FuboTV include FOX in their standard packages, allowing fans to stream the matchup easily.

Game Preview and Key Details

The 49ers are expected to start quarterback Brock Purdy, who returns from a toe injury that sidelined him for much of the season. In their last meeting, backup Mac Jones led San Francisco to a narrow 16-15 win. Purdy’s return could stabilize the offense, which struggled last week despite strong receiving performances from George Kittle and Jauan Jennings.

On the Arizona side, quarterback Jacoby Brissett will start again with Kyler Murray still out. Brissett threw for 258 yards and two touchdowns in Week 10, but turnovers proved costly. Tight end Trey McBride remains a major weapon, recording 127 yards and a score last week, while rookie Marvin Harrison Jr. continues to emerge as a deep threat.

Defensively, both teams face challenges. San Francisco has lost key starters Nick Bosa, Fred Warner, and Mykel Williams for the season. Arizona’s defense has allowed 27 or more points in three of its last four outings. Expect high scoring if both quarterbacks find rhythm early.

Expert Prediction and Analysis

According to multiple analysts, the 49ers enter as three-point road favorites. Their offensive depth gives them an edge, especially with Christian McCaffrey and Brandon Aiyuk in form. However, the weakened defense could make this a closer game than expected.

The Cardinals have been inconsistent but dangerous at home. If Brissett protects the ball, Arizona could keep it competitive. Ultimately, with Purdy’s return and McCaffrey’s dual-threat ability, San Francisco is slightly favored to pull away late.

Final Prediction: 49ers 31, Cardinals 27. Expect plenty of offense and a strong comeback statement from San Francisco.

FYI (keeping you in the loop)-

Q1: What time is the 49ers vs. Cardinals game today?

The game starts at 4:05 p.m. ET on Sunday, Nov. 16, 2025.

Q2: Where is the 49ers vs. Cardinals game being played?

The game takes place at State Farm Stadium in Glendale, Arizona.

Q3: How can I watch 49ers vs. Cardinals for free?

Fans can stream for free using DIRECTV or FuboTV’s 5-day trial offers.

Q4: Who is starting at quarterback for the 49ers?

Brock Purdy is returning as the starting quarterback after recovering from a toe injury.

Q5: What channel is broadcasting the 49ers vs. Cardinals game?

The game will air on FOX nationwide in most regions.