No. 20 USC hosts Northwestern this Friday night in a pivotal Big Ten clash. The Week 11 matchup kicks off at 9:00 p.m. ET from the Los Angeles Memorial Coliseum. The Trojans are heavy two-touchdown favorites as they continue their push for a College Football Playoff spot.This game carries major implications for both programs. USC looks to maintain its ranking, while Northwestern seeks a crucial sixth win to secure bowl eligibility. The contest will be a significant test of the Wildcats’ resilience on the road.
Northwestern’s Surprising Season Faces Ultimate Road Challenge
Northwestern has exceeded all expectations this season. The Wildcats enter this game with a 5-4 record, needing just one more victory to become bowl-eligible. This represents a massive turnaround after a four-win campaign in 2024.According to ESPN analytics, the Wildcats have been competitive in nearly every game. Their offense has found stability with SMU transfer quarterback Preston Stone. The running game is also peaking, led by Caleb Komolafe’s 125-yard performance against Nebraska.David Braun’s squad plays a disciplined style that keeps games close. They are 4-1 against the spread in their last five outings. Their sole loss in that stretch was by just a touchdown on the road.

USC’s Playoff Hopes Hinge on Home Field Dominance
The Trojans currently sit at No. 19 in the initial College Football Playoff rankings. A strong finish could see Lincoln Riley’s team break into the playoff field for the first time under his leadership. This would mark a monumental achievement for the program.Quarterback Jayden Maiava has been spectacular this season. He averages over 300 passing yards per game in home contests. His arm talent will be central to USC’s offensive game plan against a stout Northwestern defense.USC’s defense remains a concern, ranking 93rd in defensive efficiency against the run. This could prove problematic against a Northwestern team that wants to control the clock. The short week of preparation following a tough road game at Nebraska adds another layer of difficulty.
Expert Analysis Favors Wildcats to Cover Large Spread
The betting market heavily favors the Trojans as 14.5-point home favorites. However, several factors suggest Northwestern can keep this game competitive. The Wildcats are well-rested coming off a bye week, which should help mitigate the cross-country travel.Northwestern’s defense ranks 36th nationally in pass defense efficiency. This unit should be capable of limiting USC’s explosive passing attack. Their ability to control the tempo with a strong running game could shorten the game dramatically.USC’s short-week situation following a physical Nebraska game cannot be overlooked. Fatigue and preparation time become significant factors in Friday night games. Northwestern’s ball-control offense is perfectly designed to exploit these conditions.
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The final prediction sees Northwestern covering the two-touchdown spread in a closer-than-expected contest. While USC likely secures the victory, the Wildcats’ disciplined approach should keep them within the number. This USC vs Northwestern prediction hinges on Northwestern’s ability to control the clock and frustrate the Trojans’ offense.
Dropping this nugget your way
What time is the USC vs Northwestern game?
The game kicks off at 9:00 p.m. Eastern Time on Friday. It will be played at the Los Angeles Memorial Coliseum. The game will be broadcast on a major sports network.
What is the spread for the USC Northwestern game?
USC is a 14.5-point home favorite according to DraftKings Sportsbook. The total points line is set at 50.5. These odds are subject to change as kickoff approaches.
Can Northwestern become bowl eligible with a win?
Yes, a victory would give Northwestern its sixth win. This would make the team eligible for postseason bowl consideration. It would mark a significant achievement for the program.
How has USC performed at home this season?
The Trojans have been strong at home this year. Quarterback Jayden Maiava averages over 300 passing yards in Los Angeles. The team has generally taken care of business in their home stadium.
Why are experts predicting a close game despite the spread?
Northwestern’s style of play keeps games competitive. They have a strong defense and run game that controls tempo. The short week also favors the well-rested Wildcats.
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