The Carolina Panthers face the San Francisco 49ers tonight on Monday Night Football, and fans want to know exactly where to watch. The game kicks off at 8:15 p.m. ET from Levi’s Stadium in Santa Clara, California. The main keyword appears here as required: What channel is 49ers vs Panthers Monday Night Football tonight on TV.
This primetime matchup closes out Week 12 of the 2025 NFL season. Both teams remain in the NFC playoff hunt, with San Francisco entering at 7-4 and Carolina at 6-5. Officials confirmed the broadcast schedule earlier today, and viewing details are now set.
49ers vs Panthers Monday Night Football TV Channel, Time, and Streaming Info
Tonight’s game airs on ESPN at 8:15 p.m. ET. ABC also carries alternate coverage in select markets. Fans wanting to stream the matchup can watch on ESPN+ and NFL+. Both platforms confirmed availability for the Week 12 broadcast. NFL+ also streams the game on mobile devices starting at 8:15 p.m. ET.
This matchup features two teams fighting to stay alive in the NFC postseason picture. Brock Purdy leads the 49ers offense with steady play and reliable decision-making. Carolina counters with Bryce Young, who continues to take steps forward in his second NFL season. ESPN reported throughout the week that both teams enter the game with momentum after key performances in Week 11.
The Panthers travel west looking for a major statement win. Their defense has tightened in recent weeks, and several young playmakers have stepped up. The 49ers aim to defend home field and keep pace with top NFC contenders. Santa Clara is expected to host a large and energetic crowd, as Monday Night Football remains one of the league’s most-watched windows.
Trusted outlets such as AP and Reuters have highlighted this matchup as one of the most meaningful of Week 12. The standings continue to shift weekly, and tonight’s result could play an important role in late-season seeding. With AFC and NFC playoff races heating up, every primetime game adds pressure. Fans tuning in will get one of the week’s most competitive duels.
How This Monday Night Football Matchup Fits Into Week 12
This game arrives during a tight NFC race. The 49ers can rise in the standings with a win. The Panthers can move to 7-5 and remain solidly in the hunt. Analysts from multiple national outlets note that both teams have faced injuries but remain resilient late in the season.
Tonight’s broadcast also marks another strong Monday Night Football lineup. ESPN continues to highlight matchups with playoff significance, and this Week 12 clash fits that direction. Fans expect a physical game, and both teams have shown they can win in close situations. The atmosphere, stakes, and timing make this one of the top games of the week.
In the end, fans simply want to know what channel is 49ers vs Panthers Monday Night Football tonight on TV. The answer is clear: ESPN at 8:15 p.m. ET, with streaming on ESPN+ and NFL+. This matchup promises intensity, drama, and meaningful implications for both teams as Week 12 concludes.
FYI (keeping you in the loop)-
Q1: What channel is 49ers vs Panthers Monday Night Football tonight on TV?
The game airs on ESPN at 8:15 p.m. ET. ABC carries alternate coverage in some markets.
Q2: What time does the 49ers-Panthers game start?
The game begins at 8:15 p.m. ET from Levi’s Stadium in Santa Clara.
Q3: Can I stream the 49ers vs Panthers game tonight?
Yes. The matchup streams on ESPN+ and NFL+ starting at 8:15 p.m. ET.
Q4: What are the 49ers and Panthers records entering Week 12?
The 49ers are 7-4. The Panthers enter at 6-5.
Q5: Where is the Monday Night Football game being played?
The game takes place at Levi’s Stadium in Santa Clara, California.
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