Where and How to Watch Buffalo Bills vs. New England Patriots: Timeline, Prediction

The Buffalo Bills (4-0) face the New England Patriots (2-2) in a highly anticipated AFC East showdown on Sunday, October 5, 2025. The game kicks off at 8:20 p.m. ET at Highmark Stadium and will be broadcast live on NBC’s Sunday Night Football. Fans can also stream the matchup on Peacock and the official NFL app.

This divisional battle carries major early-season implications. Buffalo looks to stay undefeated and extend its dominance over the division, while New England aims to prove it’s ready to compete under new head coach Mike Vrabel.

Game Details, Matchup Notes, and Key Insights

The Bills enter Week 5 as 8.0-point favorites after a perfect start to their season. Josh Allen’s team has been dominant at home, winning 14 consecutive regular-season games in Buffalo. Since 2020, the Bills are 15-1 straight up in divisional home matchups and 15-4 in primetime contests since 2022.

Buffalo’s offense continues to thrive, with quarterback Josh Allen boasting 45 career games with both a passing and rushing touchdown — tied with Cam Newton for the most in NFL history. Running back James Cook has been a standout, rushing for 100+ yards in three straight games. Offensive coordinator Joe Brady praised Cook’s vision and understanding of the blocking schemes this week.

The Patriots have been competitive but inconsistent. Rookie quarterback Drake Maye is improving under offensive coordinator Josh McDaniels, while running backs Rhamondre Stevenson and TreVeyon Henderson remain key. However, New England’s ground game ranks just 25th in the NFL, a weakness that may limit its ability to exploit Buffalo’s 31st-ranked run defense — especially if defensive stars Ed Oliver and Matt Milano return from injury.

New England has covered the spread in four straight meetings with Buffalo, including two outright wins as underdogs. Yet, the Patriots have also struggled historically after wins — they’re 0-8 since 2023 when coming off a victory. Defensive tackle Milton Williams’ ankle injury could also weaken the Patriots’ front against Buffalo’s balanced attack.

Predictions and Expert Picks

Analysts remain split on this matchup. Many expect Buffalo to maintain its home dominance, while some see New England keeping it close.

• Pete Prisco (CBS Sports): Bills 31, Patriots 20
• Vinnie Iyer (Sporting News): Bills 34, Patriots 27
• Bill Bender (Sporting News): Bills 30, Patriots 22
• Mike Florio (Pro Football Talk): Bills 30, Patriots 23
• Chris Simms (Pro Football Talk): Patriots 27, Bills 24
• Bleacher Report panel: Split — Bills and Patriots picks divided
• ESPN FPI: Bills win probability 67.5%, projected margin +7.2

Most betting experts lean toward Buffalo winning but remain cautious about the spread. The Patriots’ ability to control possession with long drives could keep the score tighter than expected.

Final Take: Expect Buffalo to push its home winning streak to 15, but New England may keep this a one-score game deep into the second half. Josh Allen’s dual-threat ability and James Cook’s hot streak could prove decisive under the primetime lights.

FYI (keeping you in the loop)-

Q1: What time is the Buffalo Bills vs. New England Patriots game?

The game kicks off at 8:20 p.m. ET on Sunday, October 5, 2025.

Q2: Where can I watch the Bills vs. Patriots game?

You can watch live on NBC or stream via Peacock and the NFL app.

Q3: Who is favored to win Bills vs. Patriots?

The Buffalo Bills are 8.0-point favorites entering this AFC East matchup.

Q4: What are the key injuries for this game?

The Bills are monitoring Ed Oliver and Matt Milano, while the Patriots could be without DT Milton Williams due to an ankle injury.

Q5: How have the Bills performed at home?

The Bills have won 14 straight regular-season home games and are 15-1 in divisional home matchups since 2020.