Who Is Playing Monday Night Football, When Will Start Tonight

Who is playing Monday Night Football and when will start are among the most searched questions on December 22. The San Francisco 49ers face the Indianapolis Colts in a Week 16 NFL matchup at Lucas Oil Stadium in Indianapolis.

The game is scheduled for Monday, December 22, with kickoff set for 8:15 p.m. ET. The matchup has playoff implications for both teams as the regular season nears its final stretch.

Who Is Playing Monday Night Football, When Will Start and Where

Monday Night Football tonight features the San Francisco 49ers visiting the Indianapolis Colts. The game will be played indoors at Lucas Oil Stadium, one of the NFL’s premier venues.

The 49ers enter the game with a 10-4 record. They are riding a four-game winning streak and remain firmly in the NFC playoff race. San Francisco has been one of the league’s most consistent teams down the stretch.

The Colts come in at 8-6. Indianapolis is fighting to stay alive in the AFC playoff picture and needs wins to keep pace in a crowded conference race.

Kickoff is set for 8:15 p.m. Eastern Time. Viewers in other time zones can expect the game to start at 7:15 p.m. CT, 6:15 p.m. MT, and 5:15 p.m. PT.

The matchup has drawn national attention due to its late-season stakes. Prime-time Monday Night Football games often shape playoff paths, and this contest is no exception.

Key Storylines Surrounding Monday Night Football Tonight

One of the biggest storylines is the Colts’ quarterback situation. Veteran quarterback Philip Rivers returned from retirement earlier this season and is making another home start for Indianapolis.

Rivers’ presence has added experience and stability to the Colts’ offense. His leadership has been widely discussed across national media, including coverage by AP and ESPN.

For the 49ers, the focus is on momentum. San Francisco’s recent win streak has strengthened its postseason position and boosted confidence on both sides of the ball.

Injuries are also a factor. Both teams released updated injury reports ahead of kickoff, with several players listed as questionable. Teams typically finalize inactive lists about 90 minutes before the game.

Defensively, San Francisco has relied on pressure and discipline. Indianapolis has leaned on balance and ball control to stay competitive in tight games.

What This Monday Night Football Game Means Going Forward

This game carries weight beyond a single win or loss. A 49ers victory would further solidify their playoff standing and keep them in contention for seeding.

For the Colts, a win is critical. Indianapolis needs to protect home field and avoid falling behind other AFC contenders with only a few weeks left.

Monday Night Football often shapes national narratives late in the season. Performances in prime time influence playoff discussions, coaching evaluations, and roster decisions.

Who is playing Monday Night Football, when will start is now clear. The 49ers and Colts meet on December 22 at 8:15 p.m. ET in a high-stakes Week 16 showdown.

FYI (keeping you in the loop)-

Q1: Who is playing Monday Night Football tonight?

The San Francisco 49ers are playing the Indianapolis Colts. The game is part of NFL Week 16.

Q2: When will Monday Night Football start?

Kickoff is scheduled for 8:15 p.m. Eastern Time on Monday, December 22.

Q3: Where is Monday Night Football being played?

The game is being played at Lucas Oil Stadium in Indianapolis. It is an indoor venue.

Q4: Why is this Monday Night Football game important?

Both teams are competing for playoff positioning. The outcome could affect postseason chances.

Q5: How can fans follow updates during the game?

Fans can follow live broadcasts and official NFL game updates. Team injury inactives are released before kickoff.