Who Plays on Monday Night Football Tonight? 49ers vs Panthers Time, TV and Stream Guide

Who plays on Monday Night Football tonight is one of the biggest NFL Week 12 questions, and fans will get a marquee matchup between the San Francisco 49ers and the Carolina Panthers. The game kicks off tonight at 8:15 p.m. ET from Levi’s Stadium in Santa Clara. It will air on ABC and ESPN with national commentary.

The Panthers arrive with confidence behind Bryce Young, who has won six of his last eight starts. The 49ers are also trending upward with key players returning from injury, setting up a competitive NFC showdown under the prime-time lights.

Monday Night Football Tonight: Full Game Breakdown for 49ers vs Panthers

The question of who plays on Monday Night Football tonight brings sharp focus to two rising teams. Bryce Young is coming off one of the best stretches of his career. He broke the franchise passing record in Week 11 and helped Carolina stabilize after early-season struggles. His progress has created optimism around the Panthers’ offense.

Carolina continues to rely on Rico Dowdle as their lead running back. He stepped up after Chuba Hubbard suffered an injury and has performed at a high level. Coaches leaned on him heavily during the last month due to his consistency and ability to extend drives.

The 49ers are getting healthier, which is vital for their playoff chase. Brock Purdy made his return in Week 11, and so did rookie receiver Ricky Pearsall. Christian McCaffrey remains one of the most reliable players in football. George Kittle and Purdy also rediscovered their connection, scoring two touchdowns together against the Cardinals last week.

ABC and ESPN will carry tonight’s broadcast. Joe Buck and Troy Aikman lead the commentary team. Fans can also listen to the national radio call on SiriusXM channel 88. Team-specific broadcasts are available on channels 225 for San Francisco and 226 for Carolina.

This matchup is important for both teams. The Panthers want to continue building momentum around their young offense. The 49ers are fighting to stay near the top of the NFC standings while getting key players back into rhythm. Trusted outlets such as AP and Reuters have noted the importance of late-season health for San Francisco during their recent coverage of the team.

What This Week 12 Matchup Means for Both Teams

The game could shape the trajectory of both seasons. For Carolina, another strong showing from Bryce Young will deepen confidence in the franchise’s long-term direction. The coaching staff has pushed for a balanced attack, and Dowdle’s emergence supports that plan.

For San Francisco, momentum is the priority. They struggled earlier due to injuries but now appear closer to full strength. A convincing win at home in prime time would reinforce their playoff outlook and give their offense another step forward.

Tonight’s Monday Night Football matchup answers the big question of who plays on Monday Night Football tonight, and it delivers a meaningful NFC contest with playoff implications. Both teams enter confident, healthy, and motivated. Fans should expect an energized atmosphere in Santa Clara.

FYI (keeping you in the loop)-

Q1: Who plays on Monday Night Football tonight?

The 49ers host the Panthers at Levi’s Stadium. Kickoff is 8:15 p.m. ET on ABC and ESPN.

Q2: What channel is Monday Night Football on tonight?

The game airs on ABC and ESPN nationwide. It is also available on the ESPN app.

Q3: What time does Monday Night Football start?

Kickoff is set for 8:15 p.m. ET. Pre-game coverage starts earlier on ESPN.

Q4: Who is favored in the 49ers vs Panthers game?

Analysts expect a close matchup. The 49ers are viewed as strong contenders due to improved health.

Q5: How can I listen to Monday Night Football on the radio?

You can listen on SiriusXM channel 88 for the national broadcast.