Who to Start for Fantasy Football in NFL Week 4: Expert Rankings and Lineup Tips

Wondering who to start for fantasy football in Week 4? Injuries, depth chart changes, and surprising performances have made lineup decisions tricky. Our updated rankings break down the best options at every position to help you win your matchup this week.

Several stars are sidelined or limited, while new names are emerging as must-start players. Trusted sources like ESPN and NFL Network have highlighted key injury updates and role changes that could impact your fantasy lineup.

Quarterback Rankings: Who to Start for Fantasy Football

Elite quarterbacks remain reliable, but some surprising players are moving up. Here are the top QB starts for Week 4:

• Josh Allen, Bills vs. Saints
• Lamar Jackson, Ravens at Chiefs
• Jalen Hurts, Eagles at Buccaneers
• Patrick Mahomes, Chiefs vs. Ravens
• Dak Prescott, Cowboys vs. Packers
• Geno Smith, Raiders vs. Bears
• Baker Mayfield, Buccaneers vs. Eagles
• Drake Maye, Patriots vs. Panthers
• Matthew Stafford, Rams vs. Colts
• Jared Goff, Lions vs. Browns
• Justin Herbert, Chargers at Giants
• Bo Nix, Broncos vs. Bengals
• Caleb Williams, Bears at Raiders

Allen, Jackson, and Hurts headline the must-start tier. Mahomes and Prescott are strong plays in high-scoring matchups. Rookie QBs like Caleb Williams could be sneaky upside plays against weaker defenses.

Running Back Rankings: Who to Start for Fantasy Football

Running back depth is being tested after multiple injuries. These players are ranked as top Week 4 options:

• Christian McCaffrey, 49ers vs. Jaguars
• Bijan Robinson, Falcons vs. Commanders
• Jahmyr Gibbs, Lions vs. Browns
• De’Von Achane, Dolphins vs. Jets
• Josh Jacobs, Packers at Cowboys
• Saquon Barkley, Eagles at Buccaneers
• Derrick Henry, Ravens at Chiefs
• Bucky Irving, Buccaneers vs. Eagles
• James Cook III, Bills vs. Saints
• Jonathan Taylor, Colts at Rams
• Ashton Jeanty, Raiders vs. Bears
• Chase Brown, Bengals at Broncos
• Tony Pollard, Titans at Texans
• Kyren Williams, Rams vs. Colts
• Chuba Hubbard, Panthers at Patriots
• Jordan Mason, Vikings at Steelers
• Alvin Kamara, Saints at Bills
• Omarion Hampton, Chargers at Giants
• Cam Skattebo, Chargers at Giants

McCaffrey is still the safest RB1 play. Bijan Robinson and Jahmyr Gibbs have great PPR upside. Keep an eye on James Cook III and Ashton Jeanty as breakout starters this week.

Wide Receiver Rankings: Must-Start Options

Receiver matchups will decide many fantasy games this week. Here are the WRs to start with confidence:

• Puka Nacua, Rams vs. Colts
• Ja’Marr Chase, Bengals at Broncos
• Nico Collins, Texans vs. Titans
• Drake London, Falcons vs. Commanders
• Jakobi Meyers, Raiders vs. Bears
• Malik Nabers, Giants vs. Chargers
• Amon-Ra St. Brown, Lions vs. Browns
• Justin Jefferson, Vikings at Steelers
• Xavier Worthy, Chiefs vs. Ravens
• Davante Adams, Packers vs. Colts
• Tyreek Hill, Dolphins vs. Jets
• Emeka Egbuka, Buccaneers vs. Eagles
• Zay Flowers, Ravens at Chiefs
• Tetairoa McMillan, Panthers at Patriots
• George Pickens, Cowboys vs. Packers
• Ladd McConkey, Chargers at Giants
• Brian Thomas Jr., Commanders at 49ers
• Ricky Pearsall, 49ers vs. Jaguars

Ja’Marr Chase and Justin Jefferson remain elite, but Puka Nacua is now a top fantasy starter. Tyreek Hill and Amon-Ra St. Brown are matchup-proof. Watch Malik Nabers’ status after injury news.

Tight End Rankings: Reliable Starters

Tight ends continue to be unpredictable, but these players offer the best Week 4 upside:

• Brock Bowers, Raiders vs. Bears
• Travis Kelce, Chiefs vs. Ravens
• Jake Ferguson, Cowboys vs. Packers
• Tyler Warren, Colts vs. Rams
• Sam LaPorta, Lions vs. Browns
• Tucker Kraft, Packers at Cowboys
• David Njoku, Browns at Lions
• Zach Ertz, Commanders at Falcons
• Dalton Kincaid, Bills at Saints
• Dallas Goedert, Eagles at Buccaneers
• Hunter Henry, Patriots vs. Panthers
• Mark Andrews, Ravens at Chiefs
• Kyle Pitts, Falcons vs. Commanders
• Dalton Schultz, Texans vs. Titans

Travis Kelce and Brock Bowers headline the position. Sam LaPorta and Jake Ferguson are trending up. Dallas Goedert is a safe mid-tier starter against Tampa Bay.

Fantasy Outlook and Strategy

This week’s lineup decisions could swing matchups as injuries reshape depth charts. According to ESPN and NFL.com, managers should monitor last-minute game status updates, especially for Malik Nabers and Saquon Barkley. Streaming QBs like Geno Smith or rookies like Drake Maye could offer value in deeper leagues.

Fantasy owners should also consider flex options based on matchups. Players like Ashton Jeanty and James Cook III could outperform expectations. Wideouts like Puka Nacua and Nico Collins are emerging as league winners.

Final takeaway: Check injury updates, trust elite options, and use these Week 4 rankings to answer who to start for fantasy football this weekend.

FYI (keeping you in the loop)-

Q1: Who should I start at quarterback in fantasy football Week 4?

Josh Allen, Lamar Jackson, Jalen Hurts, and Patrick Mahomes are the safest QB starters.

Q2: Which running backs are must-starts this week?

Christian McCaffrey, Bijan Robinson, Jahmyr Gibbs, and De’Von Achane should be locked in.

Q3: What wide receivers have the best matchups?

Puka Nacua, Ja’Marr Chase, Tyreek Hill, and Justin Jefferson are top WR plays.

Q4: Who are good sleeper picks for Week 4 fantasy football?

James Cook III, Ashton Jeanty, and Nico Collins could outperform expectations.

Q5: Which tight ends are safe fantasy starters?

Travis Kelce, Brock Bowers, Sam LaPorta, and Jake Ferguson are top options this week.